CAJ | 학술논문

目的：观察奥沙利铂联合替吉奥（ SOX方案）治疗进展期胃癌的临床疗效及不良反应。方法58例进展期胃癌患者随机分为观察组和对照组，每组各29例。观察组化疗采用SOX方案；对照组化疗采用FOLFOX4方案（奥沙利铂＋氟尿嘧啶＋亚叶酸钙），每个化疗周期记录2组患者的不良反应，2个周期后评价疗效。结果观察组有效率为41．38％，疾病控制率为75．86％，对照组有效率为34．48％，疾病控制率为68．96％，2组比较差异无统计学意义（ P ＞0．05）；观察组白细胞下降及恶心呕吐发生率明显低于对照组，差异有统计学意义（ P ＜0．05）。其余不良反应，如红细胞下降、血小板下降、腹泻、外周神经症状、手足综合征、肝功能异常等相似，差异无统计学意义（P ＞0．05）。结论2种方案治疗进展期胃癌均具有较好的近期疗效，但SOX方案的不良反应较轻，耐受性较好，利于提高患者化疗的依从性，改善患者的生活质量。
목적：관찰오사리박연합체길오（ SOX방안）치료진전기위암적림상료효급불량반응。방법58례진전기위암환자수궤분위관찰조화대조조，매조각29례。관찰조화료채용SOX방안；대조조화료채용FOLFOX4방안（오사리박＋불뇨밀정＋아협산개），매개화료주기기록2조환자적불량반응，2개주기후평개료효。결과관찰조유효솔위41．38％，질병공제솔위75．86％，대조조유효솔위34．48％，질병공제솔위68．96％，2조비교차이무통계학의의（ P ＞0．05）；관찰조백세포하강급악심구토발생솔명현저우대조조，차이유통계학의의（ P ＜0．05）。기여불량반응，여홍세포하강、혈소판하강、복사、외주신경증상、수족종합정、간공능이상등상사，차이무통계학의의（P ＞0．05）。결론2충방안치료진전기위암균구유교호적근기료효，단SOX방안적불량반응교경，내수성교호，리우제고환자화료적의종성，개선환자적생활질량。
Objective To observe the therapeutic efficacy and adverse reactions of chemotherapy of oxaliplatine com -bined with tegafur gimeracil oteracil potassium ( SOX regimen ) in the treatment of advanced gastric cancer .Methods 58 ca-ses of advanced gastric cancer patients were randomly divided into observation group and control group , 29 cases in each group.Observation group chemotherapy using SOX regimen;chemotherapy control group using the FOLFOX 4 regimen ( oxali-platin +fluorouracil +leucovorin ) , each chemotherapy cycle recording two groups of patients with adverse reactions were evaluated after two cycles.Results In observation group effective rate was 41.38%,disease control rate was 75.86%,in con-trol group the effective rate was 34.48%, disease control rate was 68.96%, the difference was not statistically significant (P >0.05);observation group leukopenia and the incidence of nausea and vomiting was significantly lower than the control group, the difference was statistically significant ( P <0.05).The remaining adverse reactions, such as red blood cells fall, thrombocytopenia, diarrhea, peripheral neurologic symptoms, hand-foot syndrome, abnormal liver function is similar to the difference was not statistically significant ( P >0.05).Conclusion Two kinds of treatment of advanced gastric cancer have better short-term effect, but the SOX regimen mild adverse reactions , better tolerated, which will help improve patient complia nce with chemotherapy , improve the patient's quality of life.