CAJ | 학술논문

目的：观察血清同型半胱氨酸（ Hcy）、高敏C反应蛋白（ hs-CRP）及D-二聚体（D-D）水平与急性脑梗死的关系。方法选择90例急性脑梗死患者作为脑梗死组，根据梗死灶大小又分为小面积亚组（ n ＝30），中面积亚组（ n ＝24）和大面积亚组（ n ＝36），再根据临床神经功能缺损严重程度分为轻度亚组（ n ＝33）、中度亚组（ n ＝19）和重度亚组（ n ＝38）；另选同期健康体检者90例作为健康对照组。检测2组血清同型Hcy、hs-CPR及D-D水平，并作对比分析。结果脑梗死组患者血清中 Hcy、hs-CRP、D-D的含量均明显高于健康对照组（ P ＜0忖．05）；大面积亚组患者血清Hcy、hs-CRP、D-D的含量＞中面积亚组＞小面积亚组（ P ＜0．05）；重度亚组患者血清中的Hcy、hs-CRP、D-D的含量＞中度亚组＞轻度亚组（ P ＜0．05）。结论 Hcy、hs-CRP和D-D与急性脑梗死的发生发展有密切关系，检测其水平对于判断疾病的严重程度，指导临床治疗具有重要的意义。
목적：관찰혈청동형반광안산（ Hcy）、고민C반응단백（ hs-CRP）급D-이취체（D-D）수평여급성뇌경사적관계。방법선택90례급성뇌경사환자작위뇌경사조，근거경사조대소우분위소면적아조（ n ＝30），중면적아조（ n ＝24）화대면적아조（ n ＝36），재근거림상신경공능결손엄중정도분위경도아조（ n ＝33）、중도아조（ n ＝19）화중도아조（ n ＝38）；령선동기건강체검자90례작위건강대조조。검측2조혈청동형Hcy、hs-CPR급D-D수평，병작대비분석。결과뇌경사조환자혈청중 Hcy、hs-CRP、D-D적함량균명현고우건강대조조（ P ＜0촌．05）；대면적아조환자혈청Hcy、hs-CRP、D-D적함량＞중면적아조＞소면적아조（ P ＜0．05）；중도아조환자혈청중적Hcy、hs-CRP、D-D적함량＞중도아조＞경도아조（ P ＜0．05）。결론 Hcy、hs-CRP화D-D여급성뇌경사적발생발전유밀절관계，검측기수평대우판단질병적엄중정도，지도림상치료구유중요적의의。
Objective To investigate the changes of serum homocysteine ( Hcy) , high sensitivity C reactive protein ( hs-CRP) and D-dimer( D-D) levels in acute cerebral infarction patients and its significance .Methods 90 patients with a-cute cerebral infarction as cerebral infarction group , according to the infarct size , patients were divided into small-area sub-group ( n =30),middle-area subgroup ( n =24) and large-area subgroup ( n =36), according to the severity, further di-vided into mild subgroup ( n =33 ) , moderate subgroup ( n =19 ) and severe subgroup ( n =38 ) .Selected 90 cases over the same period as the healthy control group , detected serum Hcy , hs-CPR and D-D levels and to make comparative analysis . Results Serum of patients with cerebral infarction Hcy , hs-CRP, D-D levels were significantly higher than the healthy control group( P <0.05);Hcy, hs-CRP, D-D levels in large-area subgroup>middle-area subgroup>small-area subgroup ( P <0.05);serum Hcy, hs-CRP, D-D levels in severe subgroup >moderate subgroup>mild subgroup ( P <0.05) .Conclu-sion Hcy, hs-CRP and D-D and is closely related to the occurrence and development of acute cerebral infarction , the detec-tion level for judging its severity , clinical treatment has important significance .