CAJ | 학술논문

目的：观察地尔硫对经皮冠状动脉介入治疗（ PCI）术后心绞痛的临床疗效。方法冠心病PCI术后患者共180例，随机分为地尔硫治疗组102例和常规治疗对照组78例。比较治疗前后心绞痛发作次数和持续时间；术前与术后0 h、24 h、14 d、3个月时血压、心率、心肌氧耗量、C反应蛋白以及治疗前后左室射血分数（ LVEF ）、左室短轴缩短率（ LVFS）变化。结果与治疗前比较，2组治疗后心绞痛发作次数和持续时间均显著减少，且治疗组显著低于对照组（ P ＜0忖．05）；与治疗前比较，术后0 h 2组收缩压、舒张压、心率、心肌氧耗量和C反应蛋白水平均显著升高（ P ＜0．05），治疗组在术后24h、14 d、3个月亦明显低于对照组（ P ＜0．05）；治疗后2组LVEF与LVFS水平均较治疗前升高（ P ＜0．05），且治疗组均较对照组显著升高（ P ＜0．05）。2组治疗后均无明显不良反应。结论地尔硫能显著缓解PCI术后心绞痛、改善左心功能。
목적：관찰지이류대경피관상동맥개입치료（ PCI）술후심교통적림상료효。방법관심병PCI술후환자공180례，수궤분위지이류치료조102례화상규치료대조조78례。비교치료전후심교통발작차수화지속시간；술전여술후0 h、24 h、14 d、3개월시혈압、심솔、심기양모량、C반응단백이급치료전후좌실사혈분수（ LVEF ）、좌실단축축단솔（ LVFS）변화。결과여치료전비교，2조치료후심교통발작차수화지속시간균현저감소，차치료조현저저우대조조（ P ＜0촌．05）；여치료전비교，술후0 h 2조수축압、서장압、심솔、심기양모량화C반응단백수평균현저승고（ P ＜0．05），치료조재술후24h、14 d、3개월역명현저우대조조（ P ＜0．05）；치료후2조LVEF여LVFS수평균교치료전승고（ P ＜0．05），차치료조균교대조조현저승고（ P ＜0．05）。2조치료후균무명현불량반응。결론지이류능현저완해PCI술후심교통、개선좌심공능。
Objective To detect the therapeutic effect of diltiazem on angina after percutaneous coronary intervention (PCI).Methods A total of 180 patients after PCI with coronary atherosclerotic heart disease were enrolled in this analysis . All or the patients were randomly divided into diltiazem therapy group (102 patients) and non diltiazem therapy control group (78 patients).We compared the frequency and the duration of angina , the blood pressure, heart rate, myocardial oxygen con-sumption, C reactive protein ( CRP) , left ventricular function ( LVEF) and left ventricular fractional shortening ( LVFS) be-fore and after PCI on 0h, 24h, 14days and 3 months between the two groups .Results The frequency and the duration of an-gina in the therapy group were significantly lower than the control group .The systolic blood pressure , diastolic blood pressure , heart rate , myocardial oxygen consumption , and the CRP in the diltiazem therapy group were significantly lower than the con-trol group at 0h, 24h, 14 days and 3 months after PCI, and the levels of LVEF and LVFS were significantly higher than the control group ( P <0.05).Both two groups had no adverse reaction .Conclusion Diltiazem can significantly relieve the an-gina after PCI and improve the ventricular function , it is worth to use in clinical practice .