国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2014年
14期
2134-2136
,共3页
十二指肠溃疡%幽门螺旋杆菌%铝镁加混悬液%埃索美拉唑
十二指腸潰瘍%幽門螺鏇桿菌%鋁鎂加混懸液%埃索美拉唑
십이지장궤양%유문라선간균%려미가혼현액%애색미랍서
Duodenal ulcer%Helicobacter pylori%Almagate suspension%Esomeprazole
目的 观察铝镁加混悬液联用埃索美拉唑治疗幽门螺杆菌阳性十二指肠溃疡的临床疗效.方法 将幽门螺杆菌感染阳性的十二指肠溃疡患者124例随机分为两组:对照组用埃索美拉唑+阿莫西林+克拉霉素抗Hp治疗,7天后单用埃索美拉唑;治疗组用埃索美拉唑+阿莫西林+克拉霉素抗Hp治疗,7天后应用埃索美拉唑联合铝镁加混悬液;治疗4周后复查胃镜,观察十二指肠溃疡愈合情况,停药4周后复查14C呼气试验,比较两组患者溃疡愈合率、治疗有效率及Hp根除率.结果 对照组和治疗组溃疡愈合率分别为61.29％和66.13％,差异无统计学意义(P＞0.05);对照组和治疗组溃疡有效率分别为82.26％和95.16％,差异有统计学意义(x 2=5.153,P＜0.05);对照组和治疗组Hp清除率分别为82.26％和79.03％,差异无统计学意义(P＞0.05).结论 铝镁加混悬液联用埃索美拉唑治疗幽门螺杆菌阳性十二指肠溃疡的疗效优于单用埃索美拉唑.
目的 觀察鋁鎂加混懸液聯用埃索美拉唑治療幽門螺桿菌暘性十二指腸潰瘍的臨床療效.方法 將幽門螺桿菌感染暘性的十二指腸潰瘍患者124例隨機分為兩組:對照組用埃索美拉唑+阿莫西林+剋拉黴素抗Hp治療,7天後單用埃索美拉唑;治療組用埃索美拉唑+阿莫西林+剋拉黴素抗Hp治療,7天後應用埃索美拉唑聯閤鋁鎂加混懸液;治療4週後複查胃鏡,觀察十二指腸潰瘍愈閤情況,停藥4週後複查14C呼氣試驗,比較兩組患者潰瘍愈閤率、治療有效率及Hp根除率.結果 對照組和治療組潰瘍愈閤率分彆為61.29％和66.13％,差異無統計學意義(P＞0.05);對照組和治療組潰瘍有效率分彆為82.26％和95.16％,差異有統計學意義(x 2=5.153,P＜0.05);對照組和治療組Hp清除率分彆為82.26％和79.03％,差異無統計學意義(P＞0.05).結論 鋁鎂加混懸液聯用埃索美拉唑治療幽門螺桿菌暘性十二指腸潰瘍的療效優于單用埃索美拉唑.
목적 관찰려미가혼현액련용애색미랍서치료유문라간균양성십이지장궤양적림상료효.방법 장유문라간균감염양성적십이지장궤양환자124례수궤분위량조:대조조용애색미랍서+아막서림+극랍매소항Hp치료,7천후단용애색미랍서;치료조용애색미랍서+아막서림+극랍매소항Hp치료,7천후응용애색미랍서연합려미가혼현액;치료4주후복사위경,관찰십이지장궤양유합정황,정약4주후복사14C호기시험,비교량조환자궤양유합솔、치료유효솔급Hp근제솔.결과 대조조화치료조궤양유합솔분별위61.29％화66.13％,차이무통계학의의(P＞0.05);대조조화치료조궤양유효솔분별위82.26％화95.16％,차이유통계학의의(x 2=5.153,P＜0.05);대조조화치료조Hp청제솔분별위82.26％화79.03％,차이무통계학의의(P＞0.05).결론 려미가혼현액련용애색미랍서치료유문라간균양성십이지장궤양적료효우우단용애색미랍서.
Objective To observe the effect of almagate suspension in combination with esomeprazole for duodenal ulcer patients positive in Helicobacter pylori.Methods 124 duodenal ulcer patients positive in Helicobacter pylori were randomized into two groups.The control group was given esomeprazole alone after 7-day's anti-H.pylori triple therapy including esomeprazole,amoxicillin,and clarithromycin.The treatment group was treated with the same therapy plus almagate suspension.Four weeks after the treatment.both groups returned to recheck the duodenal ulcer healing by gastroscope.14C-urea breath test was (rechek) four weeks after the end of the treatment.The ulcer healing rates,total effective rates,and H.pylori eradication rates were compared between the two groups.Results There was no statistical difference in the duodenal ulcer healing rate between these two groups (61.29％ vs.66.13％,P ＞ 0.05).There was statistical difference in the duodenal ulcer total effective rate between these two groups (82.26％ vs.95.16％,x 2=5.153,P ＜ 0.05).There was no statistical difference in the duodenal ulcer H.pylori eradication rate between these two groups (82.26％ vs.79.03％,P ＞ 0.05).Conclusions Almagate suspension in combination with esomeprazole is a more effective therapy method for duodenal ulcer patients positive in Helicobacter pylori than esomeprazole alone.
