CAJ | 학술논문

黏着斑激酶(FAK)是一种非受体型酪氨酸蛋白激酶,是胞浆内重要的信号转导分子,是多种信号通路的交汇点,可参与多种细胞生长、发育、存活、增殖、凋亡及迁移等过程.近来有研究表明,FAK参与了低氧状态下肺动脉平滑肌细胞的增殖.Rho通过激活下游靶分子Rho激酶调节着细胞的收缩、黏附、迁移、增殖及凋亡等多种生物学行为.目前已证实Rho/Rock信号通路也参与了低氧状态下肺动脉平滑肌细胞的增殖.对低氧状态下FAK及Rho/Rock信号通路的研究使我们对肺动脉平滑肌细胞增殖乃至肺动脉高压形成中的可能机制有更进一步的了解,对阐明低氧性肺血管收缩及肺动脉高压形成的作用机制及防治肺动脉高压开辟新的路径具有深远的意义.
점착반격매(FAK)시일충비수체형락안산단백격매,시포장내중요적신호전도분자,시다충신호통로적교회점,가삼여다충세포생장、발육、존활、증식、조망급천이등과정.근래유연구표명,FAK삼여료저양상태하폐동맥평활기세포적증식.Rho통과격활하유파분자Rho격매조절착세포적수축、점부、천이、증식급조망등다충생물학행위.목전이증실Rho/Rock신호통로야삼여료저양상태하폐동맥평활기세포적증식.대저양상태하FAK급Rho/Rock신호통로적연구사아문대폐동맥평활기세포증식내지폐동맥고압형성중적가능궤제유경진일보적료해,대천명저양성폐혈관수축급폐동맥고압형성적작용궤제급방치폐동맥고압개벽신적로경구유심원적의의.
Focal adhesion kinase (FAK),a nonreceptor tyrosine protein kinase,a important signal transduction molecular in cytoplasm,the line intersection of a varierty of signal pathway,which promotes human pulmonary artery smooth cell(HPAMCs) proliferation in hypoxia.Rho regulates various biological behavior by activating downstream target molecular Rho-kinase (ROCK),such as cell constriction,adhesion,migration,proliferation and apoptosis.At present Rho/Rock signal pathway also have already confirmed involving in pulmonary artery smooth muscle cell proliferation in hypoxia.The study of FAK and Rho/Rock signal pathway in hypoxia make us have a better understanding about pulmonary artery smooth cell proliferation and even the possible mechanism of the formation of pulmonary hypertension,and which have a far-reaching significance to clarify the mechanism of the formation of hypoxia pulmonary vasoconstriction and pulmonary hepertension and to develop a pathway about the prevention and therapy of pulmonary hepertension.