CAJ | 학술논문

目的探讨人乳头瘤病毒(HPV)相关蛋白E6和E7及CD4-和CD8-T细胞在肺癌组织中的表达及二者的关系.方法采用免疫组织化学法检测107例肺癌患者术后组织中HPV相关蛋白E6和E7及CD4+和CD8+T细胞的表达水平.结果 107例肺癌组织中HPV相关蛋白的阳性表达率为57.94％(62/107),HPV相关蛋白表达与肺癌分化程度及吸烟史相关(x2值分别为9.483和6.683.P值均＜0.05).HPV阳性表达组与阴性表达组的CD4和CD8-T细胞的表达均存在显著性差异(x2值分别为26.533和21.266,P值均＜0.05),HPV相关蛋白表达与CD4+和CD8+T细胞的表达呈正相关(Rs=0.446,P＜0.05:Rs=0.407,P＜0.05).结论 HPV感染可引起肺癌患者机体特异性炎症反应,为肺癌的肿瘤免疫治疗提供理论基础.
목적 탐토인유두류병독(HPV)상관단백E6화E7급CD4-화CD8-T세포재폐암조직중적표체급이자적관계.방법 채용면역조직화학법검측107례폐암환자술후조직중HPV상관단백E6화E7급CD4+화CD8+T세포적표체수평.결과 107례폐암조직중HPV상관단백적양성표체솔위57.94％(62/107),HPV상관단백표체여폐암분화정도급흡연사상관(x2치분별위9.483화6.683.P치균＜0.05).HPV양성표체조여음성표체조적CD4화CD8-T세포적표체균존재현저성차이(x2치분별위26.533화21.266,P치균＜0.05),HPV상관단백표체여CD4+화CD8+T세포적표체정정상관(Rs=0.446,P＜0.05:Rs=0.407,P＜0.05).결론 HPV감염가인기폐암환자궤체특이성염증반응,위폐암적종류면역치료제공이론기출.
Objective To investigate the expressions of human papillomavirus (HPV) related protein E6,E7 and CD4+,CD8+ T cell in lung cancer and their relationship.Methods The expressions of HPV E6,E7 and CD4+,CD8 + T cell in 107 cases of lung cancer were detected hy immunohistochemistry.Results The positive expression rate of HPV in lung cancer was 57.94％ (62/107).The expression of HPV was related with degree of differentiation of lung cancer and history of smoking (x2 =9.483,P ＜0.05; x2=6.683,P ＜0.05).The expression levels of CD4+ T cell and CD8+ T cell were significantly different between the positive HPV group and the negative HPV group (x2 =26.533,P ＜0.05; x2 =21.266,P ＜0.05).There was positive correlation between the expression of HPV and levels of CD4+ T cell and CD8+ T cell in lung cancer patients (Rs=0.446,P ＜0.05; Rs=0.407,P ＜0.05).Conclusions HPV infection may cause the specific inflammatory response in lung cancer patients.That may provide a theoretical basis for lung cancer immunotherapy.