CAJ | 학술논문

目的探讨PASCAL激光与氪离子激光治疗糖尿病视网膜病变的临床疗效的差异.方法对2010年6月至2012年6月在唐山市眼科医院就诊的200例增殖前期糖尿病视网膜病变患者378只眼;另外选取200例增殖期糖尿病视网膜病变患者296只眼,以上患者按就诊时间随机分为PASCAL激光治疗的1、3组和氪离子激光治疗2、4组,治疗3个月后复查FFA、矫正视力、填写舒适度问卷调查.结果 PASCAL激光与氪离子激光治疗糖尿病视网膜病变在增殖前期患者促进无灌注区消退的疗效相似,差异无统计学意义(P ＜0.05);PASCAL激光对视力损害明显小于氪离子激光(x2=27.562,P =0.000,P＜0.01),患者对PASCAL激光的耐受性明显好于氪离子激光(x2=1.940 E,P=0.000,P ＜0.01),以上各项差异均有统计学意义;PASCAL激光在治疗增殖期患者中促进新生血管消退的作用弱于氪离子激光(2=27.562,P=0.000,P＜0.01),PASCAL激光对视力损害明显小于氪离子激光(x2=13.408,P=0.000,P＜0.01),患者对PASCAL激光的耐受性明显好于氪离子激光(x2=1.025Ea,P=0.000,P＜0.01),以上各项差异均有统计学意义.结论 PASCAL激光较氪离子激光在治疗增殖前期糖尿病视网膜病变中有一定优势,在治疗增殖期糖尿病视网膜病变效果欠佳.
목적 탐토PASCAL격광여극리자격광치료당뇨병시망막병변적림상료효적차이.방법 대2010년6월지2012년6월재당산시안과의원취진적200례증식전기당뇨병시망막병변환자378지안;령외선취200례증식기당뇨병시망막병변환자296지안,이상환자안취진시간수궤분위PASCAL격광치료적1、3조화극리자격광치료2、4조,치료3개월후복사FFA、교정시력、전사서괄도문권조사.결과 PASCAL격광여극리자격광치료당뇨병시망막병변재증식전기환자촉진무관주구소퇴적료효상사,차이무통계학의의(P ＜0.05);PASCAL격광대시력손해명현소우극리자격광(x2=27.562,P =0.000,P＜0.01),환자대PASCAL격광적내수성명현호우극리자격광(x2=1.940 E,P=0.000,P ＜0.01),이상각항차이균유통계학의의;PASCAL격광재치료증식기환자중촉진신생혈관소퇴적작용약우극리자격광(2=27.562,P=0.000,P＜0.01),PASCAL격광대시력손해명현소우극리자격광(x2=13.408,P=0.000,P＜0.01),환자대PASCAL격광적내수성명현호우극리자격광(x2=1.025Ea,P=0.000,P＜0.01),이상각항차이균유통계학의의.결론 PASCAL격광교극리자격광재치료증식전기당뇨병시망막병변중유일정우세,재치료증식기당뇨병시망막병변효과흠가.
Objective To evaluate the clinical efficacy difference of PASCAL laser and krypton ion laser treatment of diabetic retinopathy.Methods From June 2010 to June 2012 in The Eye hospital of Tangshan,200 cases (378 eyes) of pre-diabetic proliferative retinopathy and 200 cases (296 eyes) of proliferative diabetic retinopathy were randomly divided into PASCAL laser treatment groups and krypton ion laser treatment group.FFA,vision correction,and comfort questionnaire were re-examined three months after treatment.Results There were similar efficacy on promote avascular area subsided in patients with pre-proliferative diabetic retinopathy both using PASCAL laser and krypton ion laser treatment,the difference was not statistically significant.However,visual impairment was significantly less by PASCAL laser than krypton ion laser treatment (x2 27.562a,P 0.000,P ＜0.01),patients tolerated PASCAL laser significantly better than krypton ion laser (x21.940Ea,P 0.000,P ＜0.01),the above differences were statistically significant.The promoting neovascular regression role of PASCAL laser was weaker than krypton ion laser in the treatment of patients with proliferative diabetic retinopathy (x2-7.562a,P 0.000,P ＜0.01).PASCAL laser on visual impairment was significantly less than krypton ion laser (x2 13.408a,P 0.000,P ＜0.01),patients tolerated PASCAL laser significantly better than krypton ion laser (x2 1.025Ea,P 0.000,P ＜0.01),the above differences were statistically significant.Conclusions PASCAL laser compared with krypton ion laser treatment has some advantages in the early proliferative diabetic retinopathy,while the poor results in the treatment of proliferative diabetic retinopathy.