CAJ | 학술논문

目的：观察轻度贫血患者全膝关节置换术（total knee arthroplasty，TKA）前使用α-红细胞生成素（erythropoietin-α）对其输血发生情况的作用。方法：收集本院2010-2012年60例轻度贫血的TKA 患者，其中30例作为干预组在TKA术前以40000 U Epoetin-α处理3次（术前3周，1周1次），并补充铁剂、VB12和叶酸等造血物质，另外30例作为对照组不作Epoetin-α处理。观察和比较TKA患者手术前后血红蛋白含量、输血率、住院时间和手术时间等指标。结果：TKA患者术前使用Epoetin-α可使血红蛋白的量从11．5 g/dL增加至14．3 g/dL（P＜0．01）。以Epoetin-α处理的患者输血率减少（96．7％vs．56．6％P＝0．013），但干预组和对照组的住院时间相似。结论：轻度贫血患者在TKA术前3周连续使用Epoetin-α可以减少输血的发生率，但不会影响住院时间。
목적：관찰경도빈혈환자전슬관절치환술（total knee arthroplasty，TKA）전사용α-홍세포생성소（erythropoietin-α）대기수혈발생정황적작용。방법：수집본원2010-2012년60례경도빈혈적TKA 환자，기중30례작위간예조재TKA술전이40000 U Epoetin-α처리3차（술전3주，1주1차），병보충철제、VB12화협산등조혈물질，령외30례작위대조조불작Epoetin-α처리。관찰화비교TKA환자수술전후혈홍단백함량、수혈솔、주원시간화수술시간등지표。결과：TKA환자술전사용Epoetin-α가사혈홍단백적량종11．5 g/dL증가지14．3 g/dL（P＜0．01）。이Epoetin-α처리적환자수혈솔감소（96．7％vs．56．6％P＝0．013），단간예조화대조조적주원시간상사。결론：경도빈혈환자재TKA술전3주련속사용Epoetin-α가이감소수혈적발생솔，단불회영향주원시간。
Objective To observe the effects of erythropoietin-α administered before the total knee arthroplasty (TKA) on the blood transfusion in patients with mild anemia. Methods 60 patients with mild anemia, who were arranged to receive TKA , from 2010-2012 , were assigned to received either 40 000U of erythropoietin-αfor 3 times (once a week) 3 weeks before the surgery (intervention group, n=30) or not (control group, n=30). Then the hemoglobin levels , transfusion ratio , inpatient length of stay and duration of surgery between the 2 groups were analyzed. Results The hemoglobin level was increased from 11.5 g/dL to 14.3 g/dL in intervention group before the surgery (P<0.01). The blood transfusion rate was decreased from 96.6%to 56.6% (P=0.013) during the surgery. And the length of hospital stay was similar between the 2 groups. Conclusion Erythropoietin-αadministered 3 weeks before the TKA surgery could reduce the blood transfusion rate of patients with mild anemia.