昆明医科大学学报
昆明醫科大學學報
곤명의과대학학보
Journal of Kunming Medical University
2013年
9期
29-30,37
,共3页
何保丽%角建林%李波%李进涛%王丽梅
何保麗%角建林%李波%李進濤%王麗梅
하보려%각건림%리파%리진도%왕려매
树鼩%老年痴呆%天麻素%BDNF表达
樹鼩%老年癡呆%天痳素%BDNF錶達
수구%노년치태%천마소%BDNF표체
Tree shrew%Alzheimer's disease%Gastrodin%BDNF expression
目的：探讨天麻素对老年痴呆树鼩脑内海马BDNF表达的影响．方法用β-淀粉样蛋白（Aβ）侧脑室注射建立树鼩老年痴呆模型．从模型制作后第8天开始，治疗组树鼩连续30 d灌胃给予天麻素．通过RT-PCR检测海马脑源性神经营养因子（BDNF） mRNA的表达．结果海马BDNF mRNA在天马素治疗组的表达高于模型组（＜0.05）．结论天麻素能在一定程度上上调树鼩海马BDNF的表达．
目的：探討天痳素對老年癡呆樹鼩腦內海馬BDNF錶達的影響．方法用β-澱粉樣蛋白（Aβ）側腦室註射建立樹鼩老年癡呆模型．從模型製作後第8天開始，治療組樹鼩連續30 d灌胃給予天痳素．通過RT-PCR檢測海馬腦源性神經營養因子（BDNF） mRNA的錶達．結果海馬BDNF mRNA在天馬素治療組的錶達高于模型組（＜0.05）．結論天痳素能在一定程度上上調樹鼩海馬BDNF的錶達．
목적：탐토천마소대노년치태수구뇌내해마BDNF표체적영향．방법용β-정분양단백（Aβ）측뇌실주사건립수구노년치태모형．종모형제작후제8천개시，치료조수구련속30 d관위급여천마소．통과RT-PCR검측해마뇌원성신경영양인자（BDNF） mRNA적표체．결과해마BDNF mRNA재천마소치료조적표체고우모형조（＜0.05）．결론천마소능재일정정도상상조수구해마BDNF적표체．
Objective To investigate the effect of gastrodin on brain-derived neurotrophic factor (BDNF) expression in Alzheimer's disease ( AD) tree shrew. Methods AD tree shrew model was established by intracerebroventricular injection with amyloid-βpeptide (Aβ) . Since the eighth day after injection, the tree shrews were treated with gastrodin for thirty days. The expression of BDNF in tree threw hippocampus was detected by reverse transcription polymerase chain reaction (RT-PCR) . Results The expression of BDNF mRNA in the treatment group was higher than that in the model group ( <0.05) . Conclusion Gastrodin can increase some degree of the expression of BDNF.
