CAJ | 학술논문

目的探讨支气管肺泡灌洗治疗难治性肺炎患者及其血清C反应蛋白和降钙素原两项炎性指标的应用价值.方法 268例难治性肺炎患者分为灌洗组与对照组,两组进行疗效和细菌清除率的比较,并研究血清C反应蛋白和降钙素原两项指标与疗效、预后的关系.结果灌洗组的细菌清除率高于对照组(65.9％ vs 38.9％,x2=16.20,P＜O.001 6);灌洗组患者的疗效明显好于对照组,治愈率提高6.34％,显著率提高10.85％;血清C反应蛋白和降钙素原水平变化是良好的预后指标.结论支气管肺泡灌洗和血清C反应蛋白及降钙素原指标对于难治性肺炎患者具有重要的临床应用价值.
목적 탐토지기관폐포관세치료난치성폐염환자급기혈청C반응단백화강개소원량항염성지표적응용개치.방법 268례난치성폐염환자분위관세조여대조조,량조진행료효화세균청제솔적비교,병연구혈청C반응단백화강개소원량항지표여료효、예후적관계.결과 관세조적세균청제솔고우대조조(65.9％ vs 38.9％,x2=16.20,P＜O.001 6);관세조환자적료효명현호우대조조,치유솔제고6.34％,현저솔제고10.85％;혈청C반응단백화강개소원수평변화시량호적예후지표.결론 지기관폐포관세화혈청C반응단백급강개소원지표대우난치성폐염환자구유중요적림상응용개치.
Objective To evaluate the application of bronchoalveolar lavage (BAL) and usefulness of serum C-reactive protein and procalcitonin as the inflammatory indicators in patients with refractory pneumonia.Methods 268 patients with refractory pneumonia were divided into BAL group and control group.The clinical efficacy and the bacterial removal rate between two groups were compared.The relationships between the changes of the inflammatory indicators and the progression and prognosis of disease were analyzed.Results The bacterial removal rate in BAL group was higher than that in control group (65.9％ vs 38.9％,x2=16.20,P＜0.001 6).BAL markedly improved clinical efficacy of refractory pneumonia,the cure rate and the significant rate in BAL group increased by 6.34％ and 10.85％ compared to control group.The serum C-reactive protein and procalcitonin were good indicators of the prognostic development of refractory pneumonia.Conclusions Application of BAL and the serum C-reactive protein and procalcitonin as the inflammatory indicators has significant clinical value for patients with refractory pneumonia.