CAJ | 학술논문

缺血性脑血管病是临床常见病、多发病，其发病机制复杂。钙超载在缺血性脑损伤中起重要作用。瞬时受体电位M通道（transient receptor potential melastatin，TRPM）是位于细胞膜上的一类重要的非选择性阳离子通道超家族，对钙离子有较高的通透性，在缺血性脑损伤中起重要作用，对TRPM通道的研究将成为治疗缺血性脑损伤新的靶点。本文就胞内钙离子超载在缺血性脑损伤中的作用、TRPM通道及其参与的缺血性脑损伤的机制予以综述。
결혈성뇌혈관병시림상상견병、다발병，기발병궤제복잡。개초재재결혈성뇌손상중기중요작용。순시수체전위M통도（transient receptor potential melastatin，TRPM）시위우세포막상적일류중요적비선택성양리자통도초가족，대개리자유교고적통투성，재결혈성뇌손상중기중요작용，대TRPM통도적연구장성위치료결혈성뇌손상신적파점。본문취포내개리자초재재결혈성뇌손상중적작용、TRPM통도급기삼여적결혈성뇌손상적궤제여이종술。
Ischemic cerebrovascular disease is a common disease,with high incidence and complex pathogenesis. Intracellular calcium overload plays a key role in the process of cerebral ischemic injury. Transient receptor potential melastatin(TRPM) is an important class of non-selective cation channel superfamily located on the cell membrane.TRPM channel has a relatively high permeability to calcium and participates in cerebral ischemic injury. Therefore,TRPM channel will become a new target for the treatment of ischemic brain injury. This paper reviewed the role of intracellular calcium overload,TRPM channels and their participation in ischemic brain injury.