CAJ | 학술논문

采用溶剂浇铸／真空挥发／粒子沥滤法制备了径向梯度聚乳酸（PLA）多孔支架材料，对支架孔的形貌、孔径、孔隙率、压缩模量及致孔剂和溶剂残留情况等进行了研究．SEM测试结果表明，支架的孔分布均匀，孔径呈现梯度变化，且孔与孔间具有良好的相互连通性．梯度多孔支架各层的平均孔径在（175±30）-（341±23）μm之间；孔隙率均大于（87．9±1．2）％，结果表明：径向各层的孔径、孔隙率可通过致孔剂用量和粒径进行控制．压缩模量在（1．96±0．24）-（2．40±0．1）MPa之间，致孔剂用量和致孔剂粒径的变化均会导致支架力学性能的变化；TGA测试结果证实支架不存在致孔剂和溶剂残留．
채용용제요주／진공휘발／입자력려법제비료경향제도취유산（PLA）다공지가재료，대지가공적형모、공경、공극솔、압축모량급치공제화용제잔류정황등진행료연구．SEM측시결과표명，지가적공분포균균，공경정현제도변화，차공여공간구유량호적상호련통성．제도다공지가각층적평균공경재（175±30）-（341±23）μm지간；공극솔균대우（87．9±1．2）％，결과표명：경향각층적공경、공극솔가통과치공제용량화립경진행공제．압축모량재（1．96±0．24）-（2．40±0．1）MPa지간，치공제용량화치공제립경적변화균회도치지가역학성능적변화；TGA측시결과증실지가불존재치공제화용제잔류．
PLA porous gradient materials were prepared by a solvent casting/vacuum volatilization/porogenleaching （SC/VV/PL） method. The pore morphology, pore size, porosity and compression modulus ofthe scaffolds were studied. The TGA was used to test the quantities of salts and solvent remained insidethe graded scaffold. The results of SEM showed that the scaffold had homogeneous pores distribution, anda better connectivity was found between pores and pores. The average pore sizes of each layer are from 175±30μm to 341±23μm, and the porosity is up to 87.9±1.2%, which showed that each layer＇s pore sizeand porosity can be controlled by changing the particle size and the amount of the porogen. The compres-sion moduli are between 1.96±0.24MPa and 2.40±0.1MPa. The results of TGA confirmed that therewas no obvious residual of salts and solvent in the resultant scaffolds. This method allows the fabricationof radial grade macroporous PLA scaffold in a simple, homogenous, and fast way.