CAJ | 학술논문

传统硬组织修复材料由于在组成及结构上与人体骨组织存在较大差异，植入体内后的骨组织修复过程基本上是一种被动的“充填”过程，且材料的降解速度与新骨形成速度不匹配，难以达到真正的“生物性融合”，严重制约了该类材料在骨科临床的推广应用。因此，设计与制备具有“主动修复功能”和“可调控生物响应特性”的第3代新型硬组织修复材料已成为当前骨科临床的新需求和未来的发展方向。介绍了硬组织修复材料的骨再生机理研究方法，综述了硬组织修复材料与宿主防御和骨再生及宿主微环境对材料与宿主细胞相互作用的研究现状。指出硬组织修复材料植入体内后所发生的序列事件可能通过表观遗传修饰使得基因表达受材料本身和宿主微环境等因素的调控，提出新型硬组织修复材料研究中存在的问题和发展趋势。
전통경조직수복재료유우재조성급결구상여인체골조직존재교대차이，식입체내후적골조직수복과정기본상시일충피동적“충전”과정，차재료적강해속도여신골형성속도불필배，난이체도진정적“생물성융합”，엄중제약료해류재료재골과림상적추엄응용。인차，설계여제비구유“주동수복공능”화“가조공생물향응특성”적제3대신형경조직수복재료이성위당전골과림상적신수구화미래적발전방향。개소료경조직수복재료적골재생궤리연구방법，종술료경조직수복재료여숙주방어화골재생급숙주미배경대재료여숙주세포상호작용적연구현상。지출경조직수복재료식입체내후소발생적서렬사건가능통과표관유전수식사득기인표체수재료본신화숙주미배경등인소적조공，제출신형경조직수복재료연구중존재적문제화발전추세。
Traditional biomaterials for hard tissue repair in composition and structure are hugely different with human bone tissue. The repairing process of these materials is basically a passive "filling" process when implanted in the body. Because new bone formation and material degradation rate do not match well enough, it is difficult to achieve the real "bio- logical fusion", and this restricted the use of materials in orthopaedic clinical application. Therefore, design and prepara- tion of advanced third generation biomaterials for hard tissue repair with "active repair function" and "controlled biological response characteristics" has become the new demand of orthopaedic clinical application and future research direction. This paper introduced main research methods for bone regeneration mechanisms of advanced biomaterials for hard tissue re- pair, and it also summarized the current research results of interactions between these biomaterials and host cells in host microenvironment, and interactions between the biomaterials and host defense responses in the process of bone regenera- tion. These sequential events after the implantation of advanced biomaterials for hard tissue repair are apparently controlled bv ~ene rezulation, which is possible to be modified by a series of epigenetic mechanisms with many factors such as mate-rial itself and host microenvironmental factors. This paper puts forward new problems existed in the research of advanced biomaterials for hard tissue repair and development trend.