国际麻醉学与复苏杂志
國際痳醉學與複囌雜誌
국제마취학여복소잡지
INTERNATIONAL JOURNAL OF ANESTHESIOLOGY AND RESUSCITATION
2014年
3期
272-275
,共4页
急性肺损伤%机械通气诱发肺损伤%紧密连接蛋白%闭锁蛋白
急性肺損傷%機械通氣誘髮肺損傷%緊密連接蛋白%閉鎖蛋白
급성폐손상%궤계통기유발폐손상%긴밀련접단백%폐쇄단백
Acute lung injury%Ventilator-induced lung injury%Tight junction%Occludin
背景 急性肺损伤(acute lung injury,ALI)/急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)是指由心源性以外的各种肺内外致病因素所导致的急性、进行性呼吸衰竭.其发病机制错综复杂,迄今为止尚未完全阐明.机械通气诱发肺损伤(ventilation induced lung injury,VILI)是其中重要的一类,它是指应用呼吸机过程中由于机械通气诸多因素和肺部原发病共同作用导致的肺组织损伤.肺损伤过程中肺泡膜的完整性破坏及通透性的改变是根本原因,细胞连接维持肺泡膜完整性和通透性,它主要包括黏附连接(adherent junction,AJ)和紧密连接(tight junction,TJ),其中TJ在维持肺泡黏膜上皮机械屏障和肺泡膜通透性中起着更加重要的作用,TJ蛋白主要包括ZO-1、跨膜蛋白(claudin)和闭锁蛋白(occludin)等. 目的 通过对TJ蛋白occludin在机械通气诱发肺损伤中作用的研究来指导临床实践. 内容 探讨TJ蛋白occludin在机械通气诱发肺损伤中的作用. 趋向 明确连接蛋白在VILI中的作用,为临床上早期预防与治疗VILI提供理论依据.
揹景 急性肺損傷(acute lung injury,ALI)/急性呼吸窘迫綜閤徵(acute respiratory distress syndrome,ARDS)是指由心源性以外的各種肺內外緻病因素所導緻的急性、進行性呼吸衰竭.其髮病機製錯綜複雜,迄今為止尚未完全闡明.機械通氣誘髮肺損傷(ventilation induced lung injury,VILI)是其中重要的一類,它是指應用呼吸機過程中由于機械通氣諸多因素和肺部原髮病共同作用導緻的肺組織損傷.肺損傷過程中肺泡膜的完整性破壞及通透性的改變是根本原因,細胞連接維持肺泡膜完整性和通透性,它主要包括黏附連接(adherent junction,AJ)和緊密連接(tight junction,TJ),其中TJ在維持肺泡黏膜上皮機械屏障和肺泡膜通透性中起著更加重要的作用,TJ蛋白主要包括ZO-1、跨膜蛋白(claudin)和閉鎖蛋白(occludin)等. 目的 通過對TJ蛋白occludin在機械通氣誘髮肺損傷中作用的研究來指導臨床實踐. 內容 探討TJ蛋白occludin在機械通氣誘髮肺損傷中的作用. 趨嚮 明確連接蛋白在VILI中的作用,為臨床上早期預防與治療VILI提供理論依據.
배경 급성폐손상(acute lung injury,ALI)/급성호흡군박종합정(acute respiratory distress syndrome,ARDS)시지유심원성이외적각충폐내외치병인소소도치적급성、진행성호흡쇠갈.기발병궤제착종복잡,흘금위지상미완전천명.궤계통기유발폐손상(ventilation induced lung injury,VILI)시기중중요적일류,타시지응용호흡궤과정중유우궤계통기제다인소화폐부원발병공동작용도치적폐조직손상.폐손상과정중폐포막적완정성파배급통투성적개변시근본원인,세포련접유지폐포막완정성화통투성,타주요포괄점부련접(adherent junction,AJ)화긴밀련접(tight junction,TJ),기중TJ재유지폐포점막상피궤계병장화폐포막통투성중기착경가중요적작용,TJ단백주요포괄ZO-1、과막단백(claudin)화폐쇄단백(occludin)등. 목적 통과대TJ단백occludin재궤계통기유발폐손상중작용적연구래지도림상실천. 내용 탐토TJ단백occludin재궤계통기유발폐손상중적작용. 추향 명학련접단백재VILI중적작용,위림상상조기예방여치료VILI제공이론의거.
Background The acute acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a common clinical disorder characterised by injury to the alveolar epithelial and endothelial barriers of the lung,acute inflammation,and protein rich pulmonary edema leading to acute respiratory failure.The pathogenesis is complicated,it has not been fully elucidated so far.Ventilator-induced lung injury (VILI) refers to the process of applying ventilator jointly lead to pulmonary edema due to mechanical ventilation and many other factors of primary lung.It has been considered that the integrity of the alveolar membrane damage and permeability changes is the fundamental reason.Adherent junction (AJ) and tight junction (TJ) are the important structures of maintenance of epithelial barrier and permeability,and the role of TJ is more important.TJ protein includes Zo-1,claudin,occludin and so on.Objective It is of great significance to clarify the effects of TJ protein occludin in VILI.Content This review mainly discusses the research progress of TJ protein occludin in VILI.Trend Realized the role of TJ protein occludin in VILI,then provided a theoretical basis for early prevention and treatment of ventilator-induced pulmonary edema and lung injury in clinical.
