CAJ | 학술논문

以阿司匹林为模型药物制备脉冲片,并考察各处方因素对脉冲片释放度的影响.以主药和崩解剂为片芯,乙基纤维素（EC）为包衣材料,聚乙二醇6000（PEG6000）为致孔剂,羟丙甲基纤维素（HPMC）为增塑剂,采用压制包衣法制备含阿司匹林50 mg的脉冲控释片.各辅料的比例及包衣层厚度对阿司匹林片的脉冲释放均有影响.通过对处方的优化,得最终处方为主药50 mg、崩解剂30 mg,EC 180 mg,PEG6000 60 mg,HPMC 30 mg的阿司匹林脉冲控释片.通过选择片芯中的崩解剂、调整包衣层组成和厚度,可以用压制包衣的方法得到不同时间脉冲释药的阿司匹林片剂.
이아사필림위모형약물제비맥충편,병고찰각처방인소대맥충편석방도적영향.이주약화붕해제위편심,을기섬유소（EC）위포의재료,취을이순6000（PEG6000）위치공제,간병갑기섬유소（HPMC）위증소제,채용압제포의법제비함아사필림50 mg적맥충공석편.각보료적비례급포의층후도대아사필림편적맥충석방균유영향.통과대처방적우화,득최종처방위주약50 mg、붕해제30 mg,EC 180 mg,PEG6000 60 mg,HPMC 30 mg적아사필림맥충공석편.통과선택편심중적붕해제、조정포의층조성화후도,가이용압제포의적방법득도불동시간맥충석약적아사필림편제.
Pulsatile tablets of aspirin as a model drug was prepared,and all the factor that could influence the results of release are investigated.The pulsatile-release tablets containing aspirin 50 mg were prepared by press-coated methods using aspirin and disintegrants as core,ethylcellulose（EC） as coating material,PEG 6000 as pore former and HPMC as plasticizer.The pulsatile release of aspirin was influenced by the formulation of the core and the composition and thickness of the coating film.By optimizing the prescription,the final prescription was determined as aspirin 50 mg,CMS-Na 30 mg,EC 180 mg,PEG6000 60 mg,HPMC 30 mg.The pulsatile release of aspirin could be controlled by selection of disintegrants of the core and changing composition and thickness of the coating material.