中华生物医学工程杂志
中華生物醫學工程雜誌
중화생물의학공정잡지
CHINESE JOURNAL OF BIOMEDICAL ENGINEERING
2012年
4期
324-330
,共7页
腮腺肿瘤%口腔外科手术%手术后并发症%组织工程皮肤%出汗,味觉性%Meta分析
腮腺腫瘤%口腔外科手術%手術後併髮癥%組織工程皮膚%齣汗,味覺性%Meta分析
시선종류%구강외과수술%수술후병발증%조직공정피부%출한,미각성%Meta분석
Parotid neoplasms%Oral surgical procedures%Post-operative complications%Tissue engineered skin%Sweating,gustatory%Meta-analysis
目的 采用荟萃分析的方法评价组织工程皮肤(TES)预防腮腺切除术后并发症的有效性和安全性.方法 系统检索相关中英文数据库,包括CENTRAL(the Cochrane Central Register of Controlled Trials)、PubMed、EMBASE、中国期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、中文科技期刊全文数据库(VIP)、万方数字化期刊全文数据库(Wanfang)等,筛选出符合要求的25个随机对照试验,评价方法学质量并提取数据,对味觉出汗综合征(GSS)等腮腺切除术后并发症进行荟萃分析.结果 荟萃分析结果显示,与术后直接缝合相比,应用TES可以使GSS客观发生率降低84％[ RR=0.16,95％CI(0.13 ～ 0.21),P＜0.01]、GSS主观发生率降低86％ [RR=0.14,95％C/(0.10 ～ 0.19),P＜0.01];可以有效降低涎漏的发生[RR=0.23,95％CI(0.10 ～ 0.53),P＜0.01],有效改善面部凹陷畸形[RR=0.42,95％CI(0.18～0.95),P=0.04];有降低暂时性面神经麻痹发生率和增加血清积液发生率的趋势,但差异无统计学意义(均P＞0.05).结论 现有证据表明,使用TES可以有效预防腮腺切除术后GSS、面部凹陷畸形及涎漏的发生.
目的 採用薈萃分析的方法評價組織工程皮膚(TES)預防腮腺切除術後併髮癥的有效性和安全性.方法 繫統檢索相關中英文數據庫,包括CENTRAL(the Cochrane Central Register of Controlled Trials)、PubMed、EMBASE、中國期刊全文數據庫(CNKI)、中國生物醫學文獻數據庫(CBM)、中文科技期刊全文數據庫(VIP)、萬方數字化期刊全文數據庫(Wanfang)等,篩選齣符閤要求的25箇隨機對照試驗,評價方法學質量併提取數據,對味覺齣汗綜閤徵(GSS)等腮腺切除術後併髮癥進行薈萃分析.結果 薈萃分析結果顯示,與術後直接縫閤相比,應用TES可以使GSS客觀髮生率降低84％[ RR=0.16,95％CI(0.13 ～ 0.21),P＜0.01]、GSS主觀髮生率降低86％ [RR=0.14,95％C/(0.10 ～ 0.19),P＜0.01];可以有效降低涎漏的髮生[RR=0.23,95％CI(0.10 ～ 0.53),P＜0.01],有效改善麵部凹陷畸形[RR=0.42,95％CI(0.18～0.95),P=0.04];有降低暫時性麵神經痳痺髮生率和增加血清積液髮生率的趨勢,但差異無統計學意義(均P＞0.05).結論 現有證據錶明,使用TES可以有效預防腮腺切除術後GSS、麵部凹陷畸形及涎漏的髮生.
목적 채용회췌분석적방법평개조직공정피부(TES)예방시선절제술후병발증적유효성화안전성.방법 계통검색상관중영문수거고,포괄CENTRAL(the Cochrane Central Register of Controlled Trials)、PubMed、EMBASE、중국기간전문수거고(CNKI)、중국생물의학문헌수거고(CBM)、중문과기기간전문수거고(VIP)、만방수자화기간전문수거고(Wanfang)등,사선출부합요구적25개수궤대조시험,평개방법학질량병제취수거,대미각출한종합정(GSS)등시선절제술후병발증진행회췌분석.결과 회췌분석결과현시,여술후직접봉합상비,응용TES가이사GSS객관발생솔강저84％[ RR=0.16,95％CI(0.13 ～ 0.21),P＜0.01]、GSS주관발생솔강저86％ [RR=0.14,95％C/(0.10 ～ 0.19),P＜0.01];가이유효강저연루적발생[RR=0.23,95％CI(0.10 ～ 0.53),P＜0.01],유효개선면부요함기형[RR=0.42,95％CI(0.18～0.95),P=0.04];유강저잠시성면신경마비발생솔화증가혈청적액발생솔적추세,단차이무통계학의의(균P＞0.05).결론 현유증거표명,사용TES가이유효예방시선절제술후GSS、면부요함기형급연루적발생.
Objective To assess the efficacy and safety of tissue engineered skin (TES) for prevention of post-operative complications of parotidectomy by conducting a meta-analysis.Methods A total of 25 eligible randomized controlled trials were systematically searched via retrieval in Chinese and English relevant databases,including The Cochrane Central Register of Controlled Trials (CENTRAL),PubMed,EMBASE,China National Knowledge Infrastructure (CNKI),China Biomedical Literature Database (CBM),VIP Database for Chinese Technical Periodicals and Wanfang Databse.This was followed by quality appraisal and data extraction for conducting meta-analysis on the post-operative complications of parotidectomy as a result of gustatory sweating syndrome (GSS).Results As shown by the results of meta-analysis,TES resulted in a 84％ reduction in objective incidence of GSS [ RR=0.16,95％CI(0.13-0.21 ),P＜0.01 ] and a 86％ decline in subjective incidence of GSS [RR=0.14,95％ CI (0.10-0.19),P＜0.01 ] as compared with those treated with suture only.In addition,TES was associated with reduced incidence of salivary leakage [RR=0.23,95％CI(0.10-0.53),P＜0.01 ] and improved facial depressed deformity [RR=0.42,95％ CI (0.18- 0.95),P=0.04].Furthermore,TES might be associated with reduced incidence of temporal facial nerve paralysis and increased incidence of serum retention (both P＞0.05).Conclusion Current evidences suggest that TES is effective for prevention of post-parotidectomy GSS,facial depressed deformity and salivary leakage.
