当代医学
噹代醫學
당대의학
CHINA CONTEMPORARY MEDICINE
2014年
10期
140-141
,共2页
舍曲林%喹硫平%强迫症%疗效%安全性
捨麯林%喹硫平%彊迫癥%療效%安全性
사곡림%규류평%강박증%료효%안전성
Sertraline%Quetiapine%Obsessive-compulsive disorder%Clinical curative effect%Safety
目的：探讨舍曲林合并喹硫平治疗强迫症的临床疗效及安全性。方法选取广州医科大学附属脑科医院收治的强迫症患者85例，随机分为观察组（n=43）和对照组（n=42）。对照组患者给予舍曲林进行治疗，观察组患者在对照组基础上，合并喹硫平进行治疗。结果观察组患者的显效率为72.1%，显著高于对照组患者的47.6%，差异有统计学意义（χ2=5.734，P＜0.05）。2组患者治疗后的Y-BOCS和HAMA量表评分均显著低于治疗前，差异有统计学意义（P＜0.05）；观察组治疗后的Y-BOCS和HAMA量表评分下降更明显，差异有统计学意义（P＜0.05）。观察组患者出现恶心、焦虑、头痛和便秘等方面比较，差异无统计学意义；困倦和心动过速的发生率，观察组患者显著高于对照组患者，差异有统计学意义（P＜0.05）。治疗后对2组患者的血常规、尿常规、肝功能、肾功能和心电图进行检查均未出现异常。结论舍曲林联合喹硫平治疗强迫症，能显著改善患者的强迫和焦虑症状，但出现困倦和心动过速的副反应较高，治疗2周左右副反应自行消失，安全性较好，值得临床推广应用。
目的：探討捨麯林閤併喹硫平治療彊迫癥的臨床療效及安全性。方法選取廣州醫科大學附屬腦科醫院收治的彊迫癥患者85例，隨機分為觀察組（n=43）和對照組（n=42）。對照組患者給予捨麯林進行治療，觀察組患者在對照組基礎上，閤併喹硫平進行治療。結果觀察組患者的顯效率為72.1%，顯著高于對照組患者的47.6%，差異有統計學意義（χ2=5.734，P＜0.05）。2組患者治療後的Y-BOCS和HAMA量錶評分均顯著低于治療前，差異有統計學意義（P＜0.05）；觀察組治療後的Y-BOCS和HAMA量錶評分下降更明顯，差異有統計學意義（P＜0.05）。觀察組患者齣現噁心、焦慮、頭痛和便祕等方麵比較，差異無統計學意義；睏倦和心動過速的髮生率，觀察組患者顯著高于對照組患者，差異有統計學意義（P＜0.05）。治療後對2組患者的血常規、尿常規、肝功能、腎功能和心電圖進行檢查均未齣現異常。結論捨麯林聯閤喹硫平治療彊迫癥，能顯著改善患者的彊迫和焦慮癥狀，但齣現睏倦和心動過速的副反應較高，治療2週左右副反應自行消失，安全性較好，值得臨床推廣應用。
목적：탐토사곡림합병규류평치료강박증적림상료효급안전성。방법선취엄주의과대학부속뇌과의원수치적강박증환자85례，수궤분위관찰조（n=43）화대조조（n=42）。대조조환자급여사곡림진행치료，관찰조환자재대조조기출상，합병규류평진행치료。결과관찰조환자적현효솔위72.1%，현저고우대조조환자적47.6%，차이유통계학의의（χ2=5.734，P＜0.05）。2조환자치료후적Y-BOCS화HAMA량표평분균현저저우치료전，차이유통계학의의（P＜0.05）；관찰조치료후적Y-BOCS화HAMA량표평분하강경명현，차이유통계학의의（P＜0.05）。관찰조환자출현악심、초필、두통화편비등방면비교，차이무통계학의의；곤권화심동과속적발생솔，관찰조환자현저고우대조조환자，차이유통계학의의（P＜0.05）。치료후대2조환자적혈상규、뇨상규、간공능、신공능화심전도진행검사균미출현이상。결론사곡림연합규류평치료강박증，능현저개선환자적강박화초필증상，단출현곤권화심동과속적부반응교고，치료2주좌우부반응자행소실，안전성교호，치득림상추엄응용。
Objective To investigate the clinical efficacy and safety of sertraline combined with quetiapine in the treatment of obsessive-compulsive disorder.Method 85 patients with obsessive-compulsive disorder (OCD), who were enrolled in our hospital, were randomized into two groups, 43 cases in observation group, 42 cases in the control group. The control group were treated onlywith sertraline; the observation group treated combinately with sertraline and quetiapine.Results The effectual rate in the observation group was 72.1%, significantly higher than the control group (47.6%) (χ2=5.734,P<0.05). Y-BOCS and HAMA score were decreased significantly after treatment in both group (P<0.05). Y-BOCS and HAMA score decreased more significantly in the observation group, and were significantly different between the two groups. There were no significant difference between the two groups in side-reactions such as anxiety, nausea, headache and constipation are not statistically significant; But the frequency of drowsiness and tachycardia was significantly higher in the observation group. Blood routine examination, urine routine examination, liver function, kidney function and ECG were normal in both groups.Conclusion Sertraline combined with quetiapine in the treatment of OCD, can significantly improve the compulsive and anxiety symptoms, but with high frequency of drowsiness and tachycardia. The side-reactions disappeared in two weaks. Sertraline combined with quetiapine is a safe and valuable strategy in the treatment of OCD.
