北华大学学报：自然科学版
北華大學學報：自然科學版
북화대학학보：자연과학판
Journal of Beihua University(Natural Science)
2012年
1期
73-77
,共5页
胸膜肥厚%糜蛋白酶%胸膜腔感染%结核性胸膜炎%脓胸
胸膜肥厚%糜蛋白酶%胸膜腔感染%結覈性胸膜炎%膿胸
흉막비후%미단백매%흉막강감염%결핵성흉막염%농흉
residual pleural thickening%chymotrypsin%pleural cavity infection%tuberculous pleurisy%empyema
目的观察仅糜蛋白酶局部用药对胸膜腔感染所致胸膜肥厚的治疗效果．方法选择40例胸膜肥厚患者，随机分为治疗组和对照组（各20例），两组均行胸腔微管引流术．治疗组给予仅糜蛋白酶4000U加入生理盐水20mL注入胸膜腔，对照组仅予微管引流治疗．测量并记录治疗前及治疗后胸膜厚度、残腔大小及带管时间．结果治疗组应用仅糜蛋白酶胸膜腔内注射后胸膜厚度显著减低，与对照组相比差异有统计学意义（t=3.071，P＜0．01）；治疗组治疗后胸膜残腔大小与对照组相比差异有统计学意义（t=-8．82，P＜0．05）；治疗组平均带管时间为（7．25±2．53）d，比对照组（5．90±2．07）d延长，两组对比差异有统计学意义（t=2．339，P＜0．05）．结论经胸腔微管引流注入α糜蛋白酶治疗胸膜腔感染所致胸膜肥厚疗效显著，方法简便，安全高效，费用低廉，值得临床推广．
目的觀察僅糜蛋白酶跼部用藥對胸膜腔感染所緻胸膜肥厚的治療效果．方法選擇40例胸膜肥厚患者，隨機分為治療組和對照組（各20例），兩組均行胸腔微管引流術．治療組給予僅糜蛋白酶4000U加入生理鹽水20mL註入胸膜腔，對照組僅予微管引流治療．測量併記錄治療前及治療後胸膜厚度、殘腔大小及帶管時間．結果治療組應用僅糜蛋白酶胸膜腔內註射後胸膜厚度顯著減低，與對照組相比差異有統計學意義（t=3.071，P＜0．01）；治療組治療後胸膜殘腔大小與對照組相比差異有統計學意義（t=-8．82，P＜0．05）；治療組平均帶管時間為（7．25±2．53）d，比對照組（5．90±2．07）d延長，兩組對比差異有統計學意義（t=2．339，P＜0．05）．結論經胸腔微管引流註入α糜蛋白酶治療胸膜腔感染所緻胸膜肥厚療效顯著，方法簡便，安全高效，費用低廉，值得臨床推廣．
목적관찰부미단백매국부용약대흉막강감염소치흉막비후적치료효과．방법선택40례흉막비후환자，수궤분위치료조화대조조（각20례），량조균행흉강미관인류술．치료조급여부미단백매4000U가입생리염수20mL주입흉막강，대조조부여미관인류치료．측량병기록치료전급치료후흉막후도、잔강대소급대관시간．결과치료조응용부미단백매흉막강내주사후흉막후도현저감저，여대조조상비차이유통계학의의（t=3.071，P＜0．01）；치료조치료후흉막잔강대소여대조조상비차이유통계학의의（t=-8．82，P＜0．05）；치료조평균대관시간위（7．25±2．53）d，비대조조（5．90±2．07）d연장，량조대비차이유통계학의의（t=2．339，P＜0．05）．결론경흉강미관인류주입α미단백매치료흉막강감염소치흉막비후료효현저，방법간편，안전고효，비용저렴，치득림상추엄．
Objective To observe the local curative effect of α-chymotrypsin on the residual pleural thickening （RPT） caused by pleural cavity infection. Method Forty cases of RPT patients were randomly divided into treatment group and control group, （20 cases in each group ）. Microtubule drainage in the pleural cavity was performed in two groups. The patient in the treatment group were given 4 000 U α-chymotrypsin dissolved in 20mL sodium chloride and the patients in the control group were only treated with the microtubule drainage. The thickness of pleura, the size of residual cavity and the time with the tube were measured and recorded before and after the treatment. Results The pleural thickness of the patients in the treatment group after the injection of α-chymotrypsin was significantly reduced compared with that in the control group （t = 3. 071 ,P 〈 0.01 ） ; the size of residual cavity in the treatment group after the treatment was significantly different from that in the control group （t = -8.82 ,P〈0.05）. The mean time with the catheterization in the treatment group was 7.25 ± 2.53 days and that in the control group was 5.90±2.07 days,which showed that the difference in the mean time between two groups was significantly different （t = 2.339,P〈0.05 ）. Conclusion The curative effect of α-chymotrypsin on the pleural thickening caused by pleura] cavity infection is significant, the method is simple, safe and efficient, and low-cost. The method is worthy to be popularized in clinic.
