CAJ | 학술논문

let-7是目前研究最为广泛的miRNA之一,在肺癌中let-7具有抑制细胞增殖、促进细胞分化和凋亡的多种生物学功能,表明let-7与肺癌呈高度相关性.let-7可作为肺癌早期诊断和预后判断的指标.let-7发挥肿瘤抑制作用,使其在肿瘤治疗中有非常大的应用潜力.
let-7시목전연구최위엄범적miRNA지일,재폐암중let-7구유억제세포증식、촉진세포분화화조망적다충생물학공능,표명let-7여폐암정고도상관성.let-7가작위폐암조기진단화예후판단적지표.let-7발휘종류억제작용,사기재종류치료중유비상대적응용잠력.
Let-7 is one of the most widely studied miRNAs at present.Let-7 has a variety of biological functions in lung cancer,such as inhibiting cell proliferation,promoting cell differentiation and apoptosis,etc,which indicates that let-7 is highly associated with lung cancer.Let-7 might serve as an indicator in the early diagnosis and prognosis of lung cancer.Let-7 has inhibition effect on tumor,which makes it has great potential applications in cancer therapy.