CAJ | 학술논문

　　新城疫病毒是副黏病毒，对鸡的黏膜有特殊的亲嗜性，极易经呼吸道和消化道感染，利用弱毒疫苗的局部免疫作用封锁新城疫强毒的入侵门户，是防制新城疫的重要措施。本试验利用疫尅灵与新城疫活疫苗（LaSota株）分别免疫SPF鸡雏，于免疫后不同时间检测免疫鸡雏泪液中的IgA，发现疫尅灵免疫组均高于LaSota株免疫组和对照组，说明疫尅灵在新城疫免疫上具高的诱导黏膜免疫能力。
　　신성역병독시부점병독，대계적점막유특수적친기성，겁역경호흡도화소화도감염，이용약독역묘적국부면역작용봉쇄신성역강독적입침문호，시방제신성역적중요조시。본시험이용역극령여신성역활역묘（LaSota주）분별면역SPF계추，우면역후불동시간검측면역계추루액중적IgA，발현역극령면역조균고우LaSota주면역조화대조조，설명역극령재신성역면역상구고적유도점막면역능력。
Newcastle disease virus(NDV)is a member of the family of avian para-myxoviruses, highly tropic for mucous membranes, and very easy to infect chicken by Respiratory and Gastrointestinal tracts. The attenuated vaccines prevent virulent Newcastle disease virus infection through the portal entry by local mucosal immuni-ty, which is an important measure of Newcastle disease control and prevention. This experiment that SPF chicks were administrated by Yikeling vaccine and live Newcastle disease vaccine (LaSota Strain)respectively and measured the tear IgA level, re-vealed that the antibody level of Yikeling vaccine group was higher than that ob-tained in LaSota strain vaccine group and control group. The result indicated that Yikel-ing showed a better induction of mucosal immunity by Newcastle disease vaccination.