CAJ | 학술논문

1例11岁儿童患者，因服用头孢克洛4 d后出现尿黄、皮肤瘙痒入院。查肝功能异常，诊断为急性胆汁淤积型药物性肝损伤，给予保肝、退黄、降酶等对症治疗。针对患者未成年和肝损伤急性加重等特点，药学监护集中于保肝药物的合理选用、糖皮质激素个体化给药方案的制定、不良反应的监测以及药物不良相互作用的干预，同时通过用药教育提高患者用药依从性，减少潜在的用药风险。治疗4周后，患者肝功能恢复正常出院。
1례11세인동환자，인복용두포극락4 d후출현뇨황、피부소양입원。사간공능이상，진단위급성담즙어적형약물성간손상，급여보간、퇴황、강매등대증치료。침대환자미성년화간손상급성가중등특점，약학감호집중우보간약물적합리선용、당피질격소개체화급약방안적제정、불량반응적감측이급약물불량상호작용적간예，동시통과용약교육제고환자용약의종성，감소잠재적용약풍험。치료4주후，환자간공능회복정상출원。
One 11-year-old child patient with yellow urine and itching was hospitalized after taking cefaclor for 4 days. Clinical diagnosis was acute cholestatic drug-induced liver injury. Symptomatic treatments such as protecting liver function, depressing transaminase and abating jaundice were given to the patient after admission. Considering that the patient was a child and liver injury was acute exacerbation, pharmaceutical cares focused on rational selection of hepatoprotective drugs, establishment of glucocorticoid individualized treatment, adverse reactions monitoring and intervention of drug interaction. The patient's compliance increased and the potential medication risk decreased by medication education. Four weeks later, the patient was discharged with normal liver function.