中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2013年
4期
490-492
,共3页
孕妇%氧化性应激%泌尿道感染
孕婦%氧化性應激%泌尿道感染
잉부%양화성응격%비뇨도감염
Pregnant women%Oxidative stress%Urinary tract infections
目的 探讨妊娠期妇女氧化应激水平及其与泌尿系感染的关系.方法 选择188例妊娠期妇女为研究对象(观察组),以非妊娠健康女性80例为对照组.分别对妊娠期妇女和非妊娠期妇女进行过氧化氢酶(CAT)、丙二醛(MDA)和超氧化物歧化酶(SOD)检测,并分析不同妊娠分期的CAT、MDA及SOD值变化,比较非妊娠期妇女的隐性泌尿系感染(UTI)发生率与妊娠期妇女的UTI发生率的差异.结果 观察组CAT、SOD和MDA显著高于对照组[(7.47 ±0.56) U/ml,(11.62±0.96) U/ml,(2.46±0.22) nmol/mg vs (4.56±0.36) U/ml,(10.25±0.89) U/ml,(1.28±0.11) nmol/mg,P ＜0.01],且随着孕妇妊娠时间的延长,CAT、SOD和MDA均逐渐增加,差异均有统计学意义(P＜0.01).在观察组中,与非UTI患者相比,UTI患者的CAT[(3.15 ±0.49) U/ml vs(10.25 ±0.89) U/ml]和SOD[(4.38 ±0.37) U/ml vs(13.52±1.11) U/ml]较低,差异有统计学意义(P＜0.01);观察组中UTI患者MDA[(2.58 ±0.24) nmol/mg]显著高于非UTI患者[(2.43±0.21) nmol/mg],差异有统计学意义(P＜0.01);观察组泌尿系感染发生率(20.74％)显著高于对照组(10.00％),其差异有统计学意义(P＜0.05).结论 妊娠期妇女处于氧化应激状态,随着妊娠时间的延长,且氧化应激越明显,其泌尿系感染率升高,可能与妊娠期氧化应激有关.
目的 探討妊娠期婦女氧化應激水平及其與泌尿繫感染的關繫.方法 選擇188例妊娠期婦女為研究對象(觀察組),以非妊娠健康女性80例為對照組.分彆對妊娠期婦女和非妊娠期婦女進行過氧化氫酶(CAT)、丙二醛(MDA)和超氧化物歧化酶(SOD)檢測,併分析不同妊娠分期的CAT、MDA及SOD值變化,比較非妊娠期婦女的隱性泌尿繫感染(UTI)髮生率與妊娠期婦女的UTI髮生率的差異.結果 觀察組CAT、SOD和MDA顯著高于對照組[(7.47 ±0.56) U/ml,(11.62±0.96) U/ml,(2.46±0.22) nmol/mg vs (4.56±0.36) U/ml,(10.25±0.89) U/ml,(1.28±0.11) nmol/mg,P ＜0.01],且隨著孕婦妊娠時間的延長,CAT、SOD和MDA均逐漸增加,差異均有統計學意義(P＜0.01).在觀察組中,與非UTI患者相比,UTI患者的CAT[(3.15 ±0.49) U/ml vs(10.25 ±0.89) U/ml]和SOD[(4.38 ±0.37) U/ml vs(13.52±1.11) U/ml]較低,差異有統計學意義(P＜0.01);觀察組中UTI患者MDA[(2.58 ±0.24) nmol/mg]顯著高于非UTI患者[(2.43±0.21) nmol/mg],差異有統計學意義(P＜0.01);觀察組泌尿繫感染髮生率(20.74％)顯著高于對照組(10.00％),其差異有統計學意義(P＜0.05).結論 妊娠期婦女處于氧化應激狀態,隨著妊娠時間的延長,且氧化應激越明顯,其泌尿繫感染率升高,可能與妊娠期氧化應激有關.
목적 탐토임신기부녀양화응격수평급기여비뇨계감염적관계.방법 선택188례임신기부녀위연구대상(관찰조),이비임신건강녀성80례위대조조.분별대임신기부녀화비임신기부녀진행과양화경매(CAT)、병이철(MDA)화초양화물기화매(SOD)검측,병분석불동임신분기적CAT、MDA급SOD치변화,비교비임신기부녀적은성비뇨계감염(UTI)발생솔여임신기부녀적UTI발생솔적차이.결과 관찰조CAT、SOD화MDA현저고우대조조[(7.47 ±0.56) U/ml,(11.62±0.96) U/ml,(2.46±0.22) nmol/mg vs (4.56±0.36) U/ml,(10.25±0.89) U/ml,(1.28±0.11) nmol/mg,P ＜0.01],차수착잉부임신시간적연장,CAT、SOD화MDA균축점증가,차이균유통계학의의(P＜0.01).재관찰조중,여비UTI환자상비,UTI환자적CAT[(3.15 ±0.49) U/ml vs(10.25 ±0.89) U/ml]화SOD[(4.38 ±0.37) U/ml vs(13.52±1.11) U/ml]교저,차이유통계학의의(P＜0.01);관찰조중UTI환자MDA[(2.58 ±0.24) nmol/mg]현저고우비UTI환자[(2.43±0.21) nmol/mg],차이유통계학의의(P＜0.01);관찰조비뇨계감염발생솔(20.74％)현저고우대조조(10.00％),기차이유통계학의의(P＜0.05).결론 임신기부녀처우양화응격상태,수착임신시간적연장,차양화응격월명현,기비뇨계감염솔승고,가능여임신기양화응격유관.
Objective To explore the relationship between oxidative stress and urinary tract infection (UTI) during pregnancy.Methods The urine superoxide dismutase (SOD),catalase (CAT) malondialdehyde (MDA) were measured in 188 pregnant women and 80 healthy women.Results UTI was observed in 39 of 188 pregnant women.The levels of CAT,SOD,and MDA were significantly increased in pregnant women compared to nonpregnant women [(CAT:7.47 ± 0.56) U/ml vs (4.56 ± 0.36) U/ml,P＜0.01 ; SOD:(11.62 ±0.96) U/ml vs (10.25 ±0.89) U/ml,P ＜0.01 ; MDA:(2.46 ±0.22) nmol/mg vs (1.28 ± 0.11) nmol/mg,P ＜ 0.01].The activities of CAT and SOD,and the level of MDA were significantly increased from the first trimester to the third trimester in pregnancy(P ＜ 0.01).The activities of CAT in UTI group [(3.15 ± 0.49) U/ml were significantly lower that the non-UTI group (10.25 ± 0.89)U/ml] (P ＜ 0.01).The activities of SOD in the UTI goup [(4.38 ± 0.37) U/ml were significantly lower than the non-UTI group (13.52 ± 1.11)U/ml] (P ＜0.01).The level of MDA in UTI group [(2.58 ±0.24) nmol/mg] was significantly higher than the non-UTI [(2.43 ±0.21)nmol/mg] (P ＜ 0.01).The rate of UTI (20.74％) in the pregnancy was significantly higher than that in the nonpregnant women (10.00％) (P ＜ 0.05).Conclusions Oxidative stress may be the cause of UTI in pregnant women.
