CAJ | 학술논문

以环己酮、氰基乙酸乙酯与单质硫为原料通过三组分Gewald反应采用“一锅”法合成出2-氨基-4，5，6，7-四氢苯并[ b]噻吩-3-羧酸乙酯，再与水杨醛发生缩合反应制得相应的Schiff碱。目标化合物的结构经红外光谱、核磁共振氢谱、质谱和元素分析表征。
이배기동、청기을산을지여단질류위원료통과삼조분Gewald반응채용“일과”법합성출2-안기-4，5，6，7-사경분병[ b]새분-3-최산을지，재여수양철발생축합반응제득상응적Schiff감。목표화합물적결구경홍외광보、핵자공진경보、질보화원소분석표정。
The Schiff base ethyl 2-(2-hydroxybenzylideneamino)-4,5,6,7-tetrahydrobenzo [b]thio-phene-3-carboxylate was synthesized by the condensation reaction of salicylaldehyde with ethyl 2-amino-4,5,6,7-tetrahydrobenzo [ b] thiophene-3-carboxylate , which was efficiently prepared via a one-pot Gewald’s three-component reaction using cyclohexanone , ethyl 2-cyanoacetate and elemental sulfur as starting materials.The structure of the new compound was confirmed by IR , 1 H NMR, MS and elemental analysis.