CAJ | 학술논문

目的研究尖锐湿疣患者治疗后血清白介素24(IL-24)、干扰素γ(IFN-γ)和白介素4(IL-4)水平变化.方法采用双抗体夹心酶联免疫吸附法分别检测了42例尖锐湿疣患者在治疗前和治疗痊愈3个月后血清IL-24、IFN-γ和IL-4的水平,35例正常人作为对照.结果尖锐湿疣患者治疗前血清IFN-γ明显低于正常人对照组,IL-4、IL-24水平明显高于正常人对照组;治疗痊愈3个月后三者同正常人对照组无明显差异.结论尖锐湿疣患者体内细胞免疫功能受损,可能在尖锐湿疣发病中起一定作用.
목적 연구첨예습우환자치료후혈청백개소24(IL-24)、간우소γ(IFN-γ)화백개소4(IL-4)수평변화.방법 채용쌍항체협심매련면역흡부법분별검측료42례첨예습우환자재치료전화치료전유3개월후혈청IL-24、IFN-γ화IL-4적수평,35례정상인작위대조.결과 첨예습우환자치료전혈청IFN-γ명현저우정상인대조조,IL-4、IL-24수평명현고우정상인대조조;치료전유3개월후삼자동정상인대조조무명현차이.결론 첨예습우환자체내세포면역공능수손,가능재첨예습우발병중기일정작용.
Objective To investigate the changes of serum levels of IL-24, IFN-γand IL-4 in patients with condyloma acuminatum (CA) after treatment. Methods Forty-two patients with CA who experienced no recurrence within 3 months after successful treatment were enrolled in this study. Double-antibody sandwich enzyme-linked immunoabsorbent assay (DAS ELISA) was performed to determine the serum levels of IL-24,IFN-γand IL-4 in these patients before and 3 months after successful treatment as well as in 35 normal human controls. Results The untreated patients showed a lower level of serum IFN-γ (9.65 ± 3.70 vs. 15.49 ± 3.85ng/L, P ＜ 0.01) and a higher level of serum IL-4 and IL-24 (15.91 ± 6.14 vs. 10.48 ± 5.08 ng/L, 141.84 ±44.01 vs. 103.20 ± 41.37 ng/L, both P ＜ 0.01 ) compared with the controls. No significant difference was observed for the above parameters between the serum samples from the controls and patients 3 months after successful treatment. Conclusions Cellular immunity is impaired in patients with CA, which may be involved in the immunopathogenesis of CA.