CAJ | 학술논문

目的：探讨胰腺癌组织中基质金属蛋白酶9（MMP-9）的表达及其与临床病理指标和预后的关系。方法应用免疫组织化学EliVisionTM Plus法检测70例手术切除的原发性胰腺癌组织及15例癌旁无瘤胰腺组织中MMP-9的表达，并分析患者生存率、临床病理资料与MMP-9表达水平的关系。结果 MMP-9在70例原发性胰腺癌组织中的阳性率为68.6％（48/70），而在15例癌旁无瘤胰腺组织中的阳性率为26.7％（4/15），两者差异有统计学意义（χ2＝9.13， P<0.05）；MMP-9表达与性别、年龄及肿瘤部位无关，与肿瘤大小、分化程度、TNM分期、淋巴结转移显著相关（P<0.05）。MMP-9表达阴性的22例患者术后无进展生存率与总体生存率均明显长于MMP-9阳性的48例患者（χ2分别为11.84和16.09，P<0.05）。结论 MMP-9的表达与胰腺癌的临床病理指标密切相关，其高表达提示患者预后不良。
목적：탐토이선암조직중기질금속단백매9（MMP-9）적표체급기여림상병리지표화예후적관계。방법응용면역조직화학EliVisionTM Plus법검측70례수술절제적원발성이선암조직급15례암방무류이선조직중MMP-9적표체，병분석환자생존솔、림상병리자료여MMP-9표체수평적관계。결과 MMP-9재70례원발성이선암조직중적양성솔위68.6％（48/70），이재15례암방무류이선조직중적양성솔위26.7％（4/15），량자차이유통계학의의（χ2＝9.13， P<0.05）；MMP-9표체여성별、년령급종류부위무관，여종류대소、분화정도、TNM분기、림파결전이현저상관（P<0.05）。MMP-9표체음성적22례환자술후무진전생존솔여총체생존솔균명현장우MMP-9양성적48례환자（χ2분별위11.84화16.09，P<0.05）。결론 MMP-9적표체여이선암적림상병리지표밀절상관，기고표체제시환자예후불량。
Objective To investigate the expression of matrix metalloproteinases-9 (MMP-9) in pancreatic carcinoma and its clinicopathological characteristics and prognosis. Methods The expression of MMP-9 was detected in 70 pieces of primary pancreatic carcinoma and 15 pieces of non-tumor pancreatic tissues by EliVisionTM Plus immunohistochemistry method. The relationship between MMP-9 expression and survival, clinicopathological characteristics were analyzed. Results The positive rate of MMP-9 in 70 pieces of primary pancreatic carcinoma tissues was 68.6%(48/70) , and that was significantly higher than that in the 15 pieces of adjacent non-tumor pancreatic tissues(26.7%, 4/15). The expression of MMP-9 did not correlate with gender, age and the tumor position, while it was significantly correlated with the tumor size, differentiation grade, TNM stages and lymph node metastasis(P<0.05). Progression-free survival and overall survival of negative group(22 cases) were significantly longer than the positive group(48 cases),χ2=11.84, 16.09 respectively, P<0.05. Conclusions The MMP-9 expression is closely related with clinicopathological parameters of patients with pancreatic cancer. The over-expression MMP-9 may get poor prognostic predictors.