CAJ | 학술논문

目的：探讨白芍总苷对寻常型银屑病皮损面积及严重程度（ PASI）和动脉硬化生化指标的影响。方法：将73例寻常型银屑病患者随机分成2组，试验组38例给予口服白芍总苷和外用卡泊三醇治疗，对照组35例仅外用卡泊三醇。治疗前和治疗后第4、8、12周记录患者 PASI 评分，测定血清hsCRP、LDL-C、Hcy的含量。结果：两组的PASI评分在治疗前8周均呈下降趋势且试验组降低较明显，8周后只有试验组的PASI评分保持下降趋势，两组在治疗12周后的PASI评分下降幅度差异有统计学意义（礸2＝4.98，P＜0.05）；在12周后试验组hsCRP、LDL-C和HCY血清下降幅度均明显大于对照组，差异有统计学意义（ P值均＜0.05）。结论：白芍总苷能缓解寻常型银屑病严重程度，并能下调动脉硬化指标，有助于降低血管事件的风险，在长期维持治疗中可能具有一定临床价值。
목적：탐토백작총감대심상형은설병피손면적급엄중정도（ PASI）화동맥경화생화지표적영향。방법：장73례심상형은설병환자수궤분성2조，시험조38례급여구복백작총감화외용잡박삼순치료，대조조35례부외용잡박삼순。치료전화치료후제4、8、12주기록환자 PASI 평분，측정혈청hsCRP、LDL-C、Hcy적함량。결과：량조적PASI평분재치료전8주균정하강추세차시험조강저교명현，8주후지유시험조적PASI평분보지하강추세，량조재치료12주후적PASI평분하강폭도차이유통계학의의（찰2＝4.98，P＜0.05）；재12주후시험조hsCRP、LDL-C화HCY혈청하강폭도균명현대우대조조，차이유통계학의의（ P치균＜0.05）。결론：백작총감능완해심상형은설병엄중정도，병능하조동맥경화지표，유조우강저혈관사건적풍험，재장기유지치료중가능구유일정림상개치。
Objective:To explore the response of total glucosides of paeonia on treatment of se-vere psoriasis vulgaris and effect on biochemical indicators of atherosclerosis .Methods:73 pait-ients with psoriasis vulgaris were randomly classified into two groups ,experimental group was com-posed of 38 cases being treated with oral total glucosides of paeonia combined with external calci -potriene, control group was composed of 35 cases whom only being treated with external alcipot-riene.The PASI score, hsCRP,LDL-C and HCY were evaluated at baseline and 4,8,12 weeks af-ter treatment .Results:The PASI score of two groups all presented downtrend within the first eight weeks , while only experimental group showed the trend of keep going down from 8 weeks on .After 12 weeks, the decline of the PASI score in experimental group was higher than that in the control group(x2 =4.98,P<0.05).Compared with the control group, the serum level of hsCRP, LDL-C and Hcy in experimental group were statistical significantly decreased ( P<0.05 ) .Conclusion:Total glucosides of paeonia can alleviate the severity of skin lesions of patients with posoriasis vul -garis and can also decrease the risk of atherosclerosis , which can induce the cardiovascular event .