CAJ | 학술논문

目的：探讨新诊断2型糖尿病（ NDDM）患者血清脂多糖（ LPS）水平与动脉粥样硬化之间的相关性。方法检测112名NDDM患者入组时和入组1年LPS水平以及大动脉粥样硬化超声指标，并选取75名年龄、性别相匹配的健康对照，对LPS、大动脉粥样硬化超声指标及相关临床资料进行分析。结果与健康对照组相比较， NDDM患者的lnLPS水平（1．64±0．32）高于健康对照组（1．42±0．28），差异有显著性意义（P＜0．01）。采用偏相关分析发现，校正性别、年龄、病程后， LPS与入组时收缩压（ SBP）、体重指数（ BMI）、甘油三酯（ TG）、颈动脉内膜厚度（CCA-IMT）、1年时收缩压（SBP）、总胆固醇（TC）及1年时CCA差呈正相关（相关系数分别为0．312、0．287、0．274、0．187、0．231、0．295和0．287，P均＜0．05）。多元线性回归分析发现，入组时BMI、1年时CCA差是LPS独立相关因素。结论 LPS在糖尿病患者中水平升高，是引起动脉粥样硬化的危险因素。
목적：탐토신진단2형당뇨병（ NDDM）환자혈청지다당（ LPS）수평여동맥죽양경화지간적상관성。방법검측112명NDDM환자입조시화입조1년LPS수평이급대동맥죽양경화초성지표，병선취75명년령、성별상필배적건강대조，대LPS、대동맥죽양경화초성지표급상관림상자료진행분석。결과여건강대조조상비교， NDDM환자적lnLPS수평（1．64±0．32）고우건강대조조（1．42±0．28），차이유현저성의의（P＜0．01）。채용편상관분석발현，교정성별、년령、병정후， LPS여입조시수축압（ SBP）、체중지수（ BMI）、감유삼지（ TG）、경동맥내막후도（CCA-IMT）、1년시수축압（SBP）、총담고순（TC）급1년시CCA차정정상관（상관계수분별위0．312、0．287、0．274、0．187、0．231、0．295화0．287，P균＜0．05）。다원선성회귀분석발현，입조시BMI、1년시CCA차시LPS독립상관인소。결론 LPS재당뇨병환자중수평승고，시인기동맥죽양경화적위험인소。
Objective To study the relationship between Lipopolysaccharide ( LPS) and the formation of atherosclerosis in newly diagnosed type 2 diabetes mellitus .Methods Serum of 112 patients with type 2 diabetes and 75 non-diabetic sub-jects matched for age and gender were analyzed for LPS in this study .The levels of LPS and ultrasonographic studies on main arteries were performed at the time of enrollment and 1 year later .The results of ultrasonography , the levels of LPS and the other clinical data were analyzed .Results The level of lnLPS in diabetic patients (1.64 ±0.32) were significantly higher than that in non -diabetic subjects (1.42 ±0.28)(P<0.01).Partial correlation analysis showed LPS was correla-ted with the baseline systolic blood pressure (SBP) (r =0.312), body mass index (BMI) (r =0.287), triglyceride (TG) (r=0.274), Carotid artery intima-media thickness (CCA-IMT) (r=0.187), and SBP (r=0.231), total cho-lesterol (TC) (r=0.295), the change of CCA-IMT (r=0.287) after 1 year (P<0.05), adjustment for sex, age and the period of disease .Multiple regression analysis indicated that BMI at the baseline and the change of CCA -IMT 1 year later were the independent influential factors of LPS .Conclusion The lnLPS in diabetic patients were higher than that in non-diabetic subjects .LPS is a risk factor of carotid atherosclerosis .