山西医药杂志
山西醫藥雜誌
산서의약잡지
SHANXI MEDICAL JOURNAL
2013年
23期
1345-1346
,共2页
顺铂%乳腺肿瘤%多柔比星%多西他赛
順鉑%乳腺腫瘤%多柔比星%多西他賽
순박%유선종류%다유비성%다서타새
Cisplatin%Breast neoplasms%Doxorubicin%Docetaxel
目的研究多西他赛联合顺铂治疗晚期乳腺癌的临床效果,为晚期乳腺癌的治疗提供临床参考。方法将2009年1月至2012年7月我院住院治疗的224例晚期乳腺癌患者采用随机数字表法分为2组,对照组给予多西他赛联合多柔比星进行治疗,治疗组患者采用多西他赛联合顺铂进行治疗,治疗结束后评价临床疗效及不良反应发生率。结果治疗组临床总有效率为55.4%,对照组临床总有效率52.7%,2组比较差异无统计学意义( P>0.05);2组患者的不良反应以中性粒细胞减少、恶心、呕吐为主,其中治疗组患者恶心、呕吐的发生率要明显低于对照组,差异有统计学意义( P<0.05)。结论多西他赛联合顺铂治疗晚期乳腺癌临床效果显著,患者总体耐受性较好,且引起的恶心、呕吐发生率更低,更适合体质较弱的患者。
目的研究多西他賽聯閤順鉑治療晚期乳腺癌的臨床效果,為晚期乳腺癌的治療提供臨床參攷。方法將2009年1月至2012年7月我院住院治療的224例晚期乳腺癌患者採用隨機數字錶法分為2組,對照組給予多西他賽聯閤多柔比星進行治療,治療組患者採用多西他賽聯閤順鉑進行治療,治療結束後評價臨床療效及不良反應髮生率。結果治療組臨床總有效率為55.4%,對照組臨床總有效率52.7%,2組比較差異無統計學意義( P>0.05);2組患者的不良反應以中性粒細胞減少、噁心、嘔吐為主,其中治療組患者噁心、嘔吐的髮生率要明顯低于對照組,差異有統計學意義( P<0.05)。結論多西他賽聯閤順鉑治療晚期乳腺癌臨床效果顯著,患者總體耐受性較好,且引起的噁心、嘔吐髮生率更低,更適閤體質較弱的患者。
목적연구다서타새연합순박치료만기유선암적림상효과,위만기유선암적치료제공림상삼고。방법장2009년1월지2012년7월아원주원치료적224례만기유선암환자채용수궤수자표법분위2조,대조조급여다서타새연합다유비성진행치료,치료조환자채용다서타새연합순박진행치료,치료결속후평개림상료효급불량반응발생솔。결과치료조림상총유효솔위55.4%,대조조림상총유효솔52.7%,2조비교차이무통계학의의( P>0.05);2조환자적불량반응이중성립세포감소、악심、구토위주,기중치료조환자악심、구토적발생솔요명현저우대조조,차이유통계학의의( P<0.05)。결론다서타새연합순박치료만기유선암림상효과현저,환자총체내수성교호,차인기적악심、구토발생솔경저,경괄합체질교약적환자。
Objective To study the clinical effect of docetaxel and cisplatin on advanced breast cancer . Methods Two hundred and twenty-four patients with advanced breast cancer from Jan ,2009 to July ,2012 were randomly divided into treatment group and control group ;all the patients were treated with basic therapy .And the patients in control group were treated with docetaxel and doxorubicin ,the patients in treatment group was received with docetaxel and cisplatin .The clinical effect and adverse effect were compared after treatment .Results The total effective rate of treatment group was 55.4% ,and the rate of control group was 52.7% .the differences were not statistically significant between the two groups(P>0.05) .The adverse effect in the two groups were neutro-penia ,nausea and vomiting ,the rate of nausea and vomiting were lower than control (P<0 .05) .Conclusion Do-cetaxel and cisplatin shows satisfactory clinical efficacy in the treatment of breast cancer ,of which the tolerance is lower .The rate of nausea and vomiting were low ,and it is suitable for physique weaker patients ,and we must pay attention in clinical application .