CAJ | 학술논문

目的观察维生素B5（泛酸）对全饥饿大鼠脑脂质过氧化产物丙二醛（MDA）、还原型谷胱甘肽（GSH）、谷胱甘肽过氧化物酶（GSH-Px）、超氧化物歧化酶（SOD）的动态变化及保护作用。方法以饥饿昆明大鼠为模型，灌胃补充维生素B5，观察大鼠饥饿后不同时期脑MDA、GSH、GSH-Px及SOD的变化。结果饥饿后大鼠脑MDA含量明显升高，补充维生素B5后大鼠脑组织MDA含量在禁食4d与7d较饥饿前无明显升高，与全饥饿对照组比较差异有统计学意义。维生素B5对饥饿大鼠脑SOD，GSH-Px活力无影响，但显著提高GSH水平。结论维生素B5能减轻饥饿对大鼠脑组织氧化应激反应。
목적관찰유생소B5（범산）대전기아대서뇌지질과양화산물병이철（MDA）、환원형곡광감태（GSH）、곡광감태과양화물매（GSH-Px）、초양화물기화매（SOD）적동태변화급보호작용。방법이기아곤명대서위모형，관위보충유생소B5，관찰대서기아후불동시기뇌MDA、GSH、GSH-Px급SOD적변화。결과기아후대서뇌MDA함량명현승고，보충유생소B5후대서뇌조직MDA함량재금식4d여7d교기아전무명현승고，여전기아대조조비교차이유통계학의의。유생소B5대기아대서뇌SOD，GSH-Px활력무영향，단현저제고GSH수평。결론유생소B5능감경기아대대서뇌조직양화응격반응。
Objective To study the effect of vitamin B5 on lipid peroxidation in starved rats′brain .Methods To inject vitamin B5 intragastricly to starved rats ,then to examine brain MDA ,GSH content and the activity of GSH-Px and SOD at different fasting period .Results The level of MDA was significantly increased in rat′s brain after starvation .Upon vitamin B5 treatment ,there was no obvious increase of MDA between normal rats and rats starved for 5 days or 7 days .However ,when compared to the starved group ,there was significant decrease after vitamin B5 treatment .Moreover ,vitamin B5 had no effect on the activity of SOD and GSH-Px in starved rat′s brain ,but it could enhance the level of GSH .Conclusion Vitamin B5 can protect rats from harmful lipid peroxida-tion and some of the mechanisms were probably due to enhancing the level of GSH .