CAJ | 학술논문

目的：探讨急性颅脑损伤患者血清NSE和S-100 B水平变化在伤情判断及预后评估中的作用。方法：选择2010年5月～2012年5月2年间100例急性颅脑损伤患者（ GCS≤12）分别于伤后4天、24天、72天、7天时测定NSE和S100的血清浓度，同时以同期体检中心就诊的患者（均无神经系统疾病史）30例作为对照组。颅脑损伤组患者随访6个月后进行GOS评分。结果：100例颅脑损伤患者血清NSE和S100 B水平伤后均有升高，与对照组比较有显著性差异（ p＜0．05）。预后不良组与恢复良好组之间比较，伤后血清NSE和S100水平均有升高，差异有显著性（p＜0．05）。结论：血清NSE和S-100B可以作为早期评估颅脑损伤患者病情及预后的一个有价值的指标。
목적：탐토급성로뇌손상환자혈청NSE화S-100 B수평변화재상정판단급예후평고중적작용。방법：선택2010년5월～2012년5월2년간100례급성로뇌손상환자（ GCS≤12）분별우상후4천、24천、72천、7천시측정NSE화S100적혈청농도，동시이동기체검중심취진적환자（균무신경계통질병사）30례작위대조조。로뇌손상조환자수방6개월후진행GOS평분。결과：100례로뇌손상환자혈청NSE화S100 B수평상후균유승고，여대조조비교유현저성차이（ p＜0．05）。예후불량조여회복량호조지간비교，상후혈청NSE화S100수평균유승고，차이유현저성（p＜0．05）。결론：혈청NSE화S-100B가이작위조기평고로뇌손상환자병정급예후적일개유개치적지표。
Objective:To investigate the Changes of Serum NSE and s -100B Levels in Patients with traumatic brain injury and its re-lation with the severity and Clinical outcome of TBI .Methods:One-hundred patients suffering from TBI ( Glasgow coma score ≤12 ) were included , and 30 healthy volunteers were recruited as control in the study .Serum levels of NSE and s-100 B protein were measured by electrochemiluminescence immunoassay .All patients of the experimental group have Glasgow outcome scale after 6 months.Results:In traumatic brain injury patients ,the NSE and s-100B levels in serum increased significantly , and the difference was significant compared with the control(P<0.05).Two groups according to Glasgow outcome scale , the higher of NSE and s-100B levels in serum, the progno-sis was worse (P<0.05).Conclusion:This human study indicates that Serum NSE and s -100B levels may be used as promising markers for evaluating severity and prognosis of TBI ,especially in the patients at earlier post -traumatic interval .