安徽医学
安徽醫學
안휘의학
ANHUI MEDICAL JOURNAL
2014年
3期
304-307
,共4页
冠心病%脂蛋白a%N末端脑钠肽前体%冠状动脉造影
冠心病%脂蛋白a%N末耑腦鈉肽前體%冠狀動脈造影
관심병%지단백a%N말단뇌납태전체%관상동맥조영
Coronary heart disease%Lipoprotein a%N-terminal fragment of the prohormone brain-type natriuretic peptide%Coronary arteriography
目的：探讨脂蛋白a[LP（a）]与N末端脑钠肽前体（NT-proBNP）在冠心病及冠状动脉狭窄程度中的作用。方法连续性收集我科行冠状动脉造影的患者121例，根据造影结果将患者分为冠心病组89例与对照组32例，对2组患者的临床及实验室资料，采用单因素和多因素Logistic回归分析LP（a）及NT-proBNP与冠心病及冠状动脉狭窄程度的关系。结果①单因素分析发现冠心病组中男性比例、LDL-C、LP（a）与NT-proBNP水平均高于对照组（P＜0．05），HDL-C水平低于对照组（P＜0．05），多因素Logistic回归分析仅NT-proBNP水平是冠心病的独立危险因素（OR：1．002，95％ CI：1．001～1．003；P＝0．003）。②冠状动脉中度狭窄组与轻度狭窄组比较：LP（a）、NT-proBNP水平均高于轻度狭窄组（P值分别为0．002，0．044），冠状动脉重度狭窄组与轻度狭窄组比较：LP（a）、NT-proBNP水平均高于轻度狭窄组（P值分别为0．001，＜0．001），随着冠状动脉狭窄程度加重，LP（a）、NT-proBNP水平呈增高趋势。结论 NT-proBNP是冠心病的独立危险因素，而LP（a）、NT-proBNP水平均与冠脉狭窄程度存在显著相关性。
目的：探討脂蛋白a[LP（a）]與N末耑腦鈉肽前體（NT-proBNP）在冠心病及冠狀動脈狹窄程度中的作用。方法連續性收集我科行冠狀動脈造影的患者121例，根據造影結果將患者分為冠心病組89例與對照組32例，對2組患者的臨床及實驗室資料，採用單因素和多因素Logistic迴歸分析LP（a）及NT-proBNP與冠心病及冠狀動脈狹窄程度的關繫。結果①單因素分析髮現冠心病組中男性比例、LDL-C、LP（a）與NT-proBNP水平均高于對照組（P＜0．05），HDL-C水平低于對照組（P＜0．05），多因素Logistic迴歸分析僅NT-proBNP水平是冠心病的獨立危險因素（OR：1．002，95％ CI：1．001～1．003；P＝0．003）。②冠狀動脈中度狹窄組與輕度狹窄組比較：LP（a）、NT-proBNP水平均高于輕度狹窄組（P值分彆為0．002，0．044），冠狀動脈重度狹窄組與輕度狹窄組比較：LP（a）、NT-proBNP水平均高于輕度狹窄組（P值分彆為0．001，＜0．001），隨著冠狀動脈狹窄程度加重，LP（a）、NT-proBNP水平呈增高趨勢。結論 NT-proBNP是冠心病的獨立危險因素，而LP（a）、NT-proBNP水平均與冠脈狹窄程度存在顯著相關性。
목적：탐토지단백a[LP（a）]여N말단뇌납태전체（NT-proBNP）재관심병급관상동맥협착정도중적작용。방법련속성수집아과행관상동맥조영적환자121례，근거조영결과장환자분위관심병조89례여대조조32례，대2조환자적림상급실험실자료，채용단인소화다인소Logistic회귀분석LP（a）급NT-proBNP여관심병급관상동맥협착정도적관계。결과①단인소분석발현관심병조중남성비례、LDL-C、LP（a）여NT-proBNP수평균고우대조조（P＜0．05），HDL-C수평저우대조조（P＜0．05），다인소Logistic회귀분석부NT-proBNP수평시관심병적독립위험인소（OR：1．002，95％ CI：1．001～1．003；P＝0．003）。②관상동맥중도협착조여경도협착조비교：LP（a）、NT-proBNP수평균고우경도협착조（P치분별위0．002，0．044），관상동맥중도협착조여경도협착조비교：LP（a）、NT-proBNP수평균고우경도협착조（P치분별위0．001，＜0．001），수착관상동맥협착정도가중，LP（a）、NT-proBNP수평정증고추세。결론 NT-proBNP시관심병적독립위험인소，이LP（a）、NT-proBNP수평균여관맥협착정도존재현저상관성。
Objective To investigate the effect of lipoprotein a[LP(a)]and N-terminal fragment of the prohormone brain-type na-triuretic peptide(NT-proBNP)on coronary heart disease and the degree of coronary artery stenosis.Methods A total of 121 patients under-went coronary angiography were continuously collected in our hospital,who were divided into coronary heart disease group with 89 patients and the control group with 32 patients,according to the results of coronary angiography.Clinical data and laboratory indexes were recorded in all patients.The single factor and multivariate logistic regression analysis were used to analyze the correlation between LP(a)and NT-proBNP and coronary heart disease and coronary artery stenosis degree.Results ①Univariate analysis revealed the proportion of male patients,and the level of LDL,LP(a)and NT-proBNP in coronary heart disease group were higher than those in control group(P<0.05 ).However,the HDL level was lower than control group(P<0.05 ).Multivariate logistic regression analysis showed that and the level of NT-proBNP(OR 1.002,95%CI:1.001~1.003;P=0.003)was an independent risk factor for coronary heart disease.②Comparison of coronary artery stenosis in patients with moderate and mild stenosis:the LP(a)level and NT-proBNP level were higher than those in mild stenosis (P=0.002, 0.044).Compared to mild coronary artery stenosis,the LP(a)level and NT-proBNP level were higher in severe stenosis (P=0.001,<0.001).With the degree of coronary artery stenosis aggravating,the level of LP(a)and NT-proBNP also increased.Conclusion The level of NT-proBNP is an independent risk factor for coronary heart disease.The LP(a)level and NT-proBNP level are significantly associated with the degree of coronary artery stenosis.
