安徽医学
安徽醫學
안휘의학
ANHUI MEDICAL JOURNAL
2014年
3期
288-290,291
,共4页
程方月%黄淑婷%张锐%张明铭%徐建华
程方月%黃淑婷%張銳%張明銘%徐建華
정방월%황숙정%장예%장명명%서건화
结缔组织病%间质性肺炎%维生素D%肺功能
結締組織病%間質性肺炎%維生素D%肺功能
결체조직병%간질성폐염%유생소D%폐공능
Connective tissue disease%Interstitial pneumonia%Vitamin D%Lung function
目的:探讨结缔组织病合并肺间质病变(CTD-ILD)患者血清25羟基维生素D[25(OH)D]的水平变化及临床意义。方法收集40例CTD-ILD患者为CTD-ILD组,健康对照组30例,采用酶联免疫吸附试验(ELISA)法测定CTD-ILD患者的血清25(OH)D浓度,评价25(OH)D与临床指标的相关性。结果 CTD-ILD组25(OH)D平均水平明显低于正常对照组,差异有统计学意义(t=-6.999,P<0.05)。25(OH)D水平与CTD-ILD患者体质量指数(BMI)、血沉(ESR)呈负相关(r=-0.374,-0.372, P<0.05),与患者用力肺活量占预计值百分比(FVC%)呈正相关(r=0.352,P<0.05)。多发性肌炎/皮肌炎(PM/DM)-ILD与系统性硬皮病(SSc)-ILD组的FVC%水平低于其他类型CTD-ILD的FVC%水平,差异有统计学意义(t=2.055,P<0.05)。根据肺功能水平高低,分为肺功能正常组、轻度肺功能损伤组、中度肺功能损伤组及重度肺功能损伤组,4组间的25(OH)D水平呈依次下降趋势,且相互间差异有统计学意义(P<0.05),正常组及轻度损伤组25(OH)D水平显著高于中度及重度肺功能损伤组,差异有统计学意义(P<0.05)。结论 CTD-ILD组患者血清25(OH)D水平显著低下,且与肺功能的减退有关,在CTD-ILD的发病机制中可能发挥作用。
目的:探討結締組織病閤併肺間質病變(CTD-ILD)患者血清25羥基維生素D[25(OH)D]的水平變化及臨床意義。方法收集40例CTD-ILD患者為CTD-ILD組,健康對照組30例,採用酶聯免疫吸附試驗(ELISA)法測定CTD-ILD患者的血清25(OH)D濃度,評價25(OH)D與臨床指標的相關性。結果 CTD-ILD組25(OH)D平均水平明顯低于正常對照組,差異有統計學意義(t=-6.999,P<0.05)。25(OH)D水平與CTD-ILD患者體質量指數(BMI)、血沉(ESR)呈負相關(r=-0.374,-0.372, P<0.05),與患者用力肺活量佔預計值百分比(FVC%)呈正相關(r=0.352,P<0.05)。多髮性肌炎/皮肌炎(PM/DM)-ILD與繫統性硬皮病(SSc)-ILD組的FVC%水平低于其他類型CTD-ILD的FVC%水平,差異有統計學意義(t=2.055,P<0.05)。根據肺功能水平高低,分為肺功能正常組、輕度肺功能損傷組、中度肺功能損傷組及重度肺功能損傷組,4組間的25(OH)D水平呈依次下降趨勢,且相互間差異有統計學意義(P<0.05),正常組及輕度損傷組25(OH)D水平顯著高于中度及重度肺功能損傷組,差異有統計學意義(P<0.05)。結論 CTD-ILD組患者血清25(OH)D水平顯著低下,且與肺功能的減退有關,在CTD-ILD的髮病機製中可能髮揮作用。
목적:탐토결체조직병합병폐간질병변(CTD-ILD)환자혈청25간기유생소D[25(OH)D]적수평변화급림상의의。방법수집40례CTD-ILD환자위CTD-ILD조,건강대조조30례,채용매련면역흡부시험(ELISA)법측정CTD-ILD환자적혈청25(OH)D농도,평개25(OH)D여림상지표적상관성。결과 CTD-ILD조25(OH)D평균수평명현저우정상대조조,차이유통계학의의(t=-6.999,P<0.05)。25(OH)D수평여CTD-ILD환자체질량지수(BMI)、혈침(ESR)정부상관(r=-0.374,-0.372, P<0.05),여환자용력폐활량점예계치백분비(FVC%)정정상관(r=0.352,P<0.05)。다발성기염/피기염(PM/DM)-ILD여계통성경피병(SSc)-ILD조적FVC%수평저우기타류형CTD-ILD적FVC%수평,차이유통계학의의(t=2.055,P<0.05)。근거폐공능수평고저,분위폐공능정상조、경도폐공능손상조、중도폐공능손상조급중도폐공능손상조,4조간적25(OH)D수평정의차하강추세,차상호간차이유통계학의의(P<0.05),정상조급경도손상조25(OH)D수평현저고우중도급중도폐공능손상조,차이유통계학의의(P<0.05)。결론 CTD-ILD조환자혈청25(OH)D수평현저저하,차여폐공능적감퇴유관,재CTD-ILD적발병궤제중가능발휘작용。
Objective To investigate the connective tissue disease associated interstitial lung disease (CTD-ILD ) serum 25-hydroxyvitamin D [25 (OH)D]levels and its clinical significance.Methods Forty cases of CTD-ILD and 30 patients with healthy controls were selected.The serum 25 (OH)D levels were measured by ELISA.T-test and one-way ANOVA were used for date analysis,and Pearson's test was adopted for correlation analysis.Results 25 (OH)D levels of CTD-ILD group were significantly lower than those of the normal con-trol group (t=-6.999,P<0.05);25 (OH)D levels in patients was negatively correlated with CTD-ILD body mass index (BMI)and e-rythrocyte sedimentation rate (ESR)(r=-0.374,-0.372,P<0.05 ),and was positively correlated with the patient percentage of predic-ted forced vital capacity (FVC%)(r=0.352,P<0.05);FVC%of PM/DM-ILD and SSc-ILD group was lower than that of other types of CTD-ILD,and the difference was statistically significant (t=2.055,P<0.05 ).According to the level of lung function,the patients were di-vided into normal group,mild lung injury group,moderate and severe lung injury group,and 25 (OH)D levels of four groups were followed by a downward trend and mutual differences were statistically significant (P<0.05).Further comparison among groups showed 25 (OH)D lev-els of normal group and mild group were significantly higher than those of moderate and severe lung injury group (P<0.05).Conclusion Serum 25 (OH)D levels of CTD-ILD group were significantly low,which is correlated with the decrease in lung function and plays a role in the pathogenesis of CTD-ILD.