国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2013年
7期
956-958
,共3页
去氧孕烯炔雌醇片%醋酸甲羟孕酮片%围绝经期%功能失调性子宫出血%性激素
去氧孕烯炔雌醇片%醋痠甲羥孕酮片%圍絕經期%功能失調性子宮齣血%性激素
거양잉희결자순편%작산갑간잉동편%위절경기%공능실조성자궁출혈%성격소
Desogestrel and ethinyl estradiol tablets%Medroxyprogesterone acetate tablets%Perimenopausal period%Dysfunctional uterine bleeding%Sex hormones
目的 探讨去氧孕烯炔雌醇治疗绝经过渡期功能失调性子宫出血(功血)的临床疗效及对血清性激素水平的影响.方法 选择2010年4月至2012年10月在本院治疗并确诊为绝经过渡期功血患者94例,随机分为观察组和对照组,各47例.观察组在诊断性刮宫术后3天给予去氧孕烯炔雌醇治疗,对照组在诊断性刮宫术后3天给予醋酸甲羟孕酮片治疗.对比观察两组止血时间、临床疗效和药物不良反应.检测患者治疗前后促卵泡生成素(FSH)、黄体生成素(LH)、雌激素(E2)的水平.结果 观察组临床疗效总有效率为97.87％,明显高于对照组53.19％,差异有统计学意义(P＜0.05)；观察组控制出血时间和完全止血时间均低于对照组,差异有统计学意义(P＜0.05).治疗后观察组FSH水平明显下降,与对照组和本组治疗前比较,差异有统计学意义(P＜0.05)；而LH、E2水平与治疗前比较,差异无统计学意义(P＞0.05).对照组治疗前后FSH、LH和E2的水平比较,差异无统计学意义(P＞0.05).对照组不良反应率高于观察组,差异有统计学意义(P＜0.05).结论 去氧孕烯炔雌醇在围绝经期功血患者止血中安全有效,值得临床应用.
目的 探討去氧孕烯炔雌醇治療絕經過渡期功能失調性子宮齣血(功血)的臨床療效及對血清性激素水平的影響.方法 選擇2010年4月至2012年10月在本院治療併確診為絕經過渡期功血患者94例,隨機分為觀察組和對照組,各47例.觀察組在診斷性颳宮術後3天給予去氧孕烯炔雌醇治療,對照組在診斷性颳宮術後3天給予醋痠甲羥孕酮片治療.對比觀察兩組止血時間、臨床療效和藥物不良反應.檢測患者治療前後促卵泡生成素(FSH)、黃體生成素(LH)、雌激素(E2)的水平.結果 觀察組臨床療效總有效率為97.87％,明顯高于對照組53.19％,差異有統計學意義(P＜0.05)；觀察組控製齣血時間和完全止血時間均低于對照組,差異有統計學意義(P＜0.05).治療後觀察組FSH水平明顯下降,與對照組和本組治療前比較,差異有統計學意義(P＜0.05)；而LH、E2水平與治療前比較,差異無統計學意義(P＞0.05).對照組治療前後FSH、LH和E2的水平比較,差異無統計學意義(P＞0.05).對照組不良反應率高于觀察組,差異有統計學意義(P＜0.05).結論 去氧孕烯炔雌醇在圍絕經期功血患者止血中安全有效,值得臨床應用.
목적 탐토거양잉희결자순치료절경과도기공능실조성자궁출혈(공혈)적림상료효급대혈청성격소수평적영향.방법 선택2010년4월지2012년10월재본원치료병학진위절경과도기공혈환자94례,수궤분위관찰조화대조조,각47례.관찰조재진단성괄궁술후3천급여거양잉희결자순치료,대조조재진단성괄궁술후3천급여작산갑간잉동편치료.대비관찰량조지혈시간、림상료효화약물불량반응.검측환자치료전후촉란포생성소(FSH)、황체생성소(LH)、자격소(E2)적수평.결과 관찰조림상료효총유효솔위97.87％,명현고우대조조53.19％,차이유통계학의의(P＜0.05)；관찰조공제출혈시간화완전지혈시간균저우대조조,차이유통계학의의(P＜0.05).치료후관찰조FSH수평명현하강,여대조조화본조치료전비교,차이유통계학의의(P＜0.05)；이LH、E2수평여치료전비교,차이무통계학의의(P＞0.05).대조조치료전후FSH、LH화E2적수평비교,차이무통계학의의(P＞0.05).대조조불량반응솔고우관찰조,차이유통계학의의(P＜0.05).결론 거양잉희결자순재위절경기공혈환자지혈중안전유효,치득림상응용.
Objective To explore the clinical efficacy of desogestrel and ethinyl estradiol tablet for perimenopausal dysfunctional uterine bleeding (PDUB) and the effect of this agent on sex hormones.Methods A total of 94 patients with PDUB who had been hospitalized from April 2010 to October 2012 were randomly divided into a study group and a control group.The study group received desogestrel and ethinyl estradiol tablets starting from the third day after diagnostic curettage,while the control group received medroxyprogesterone acetate.Time to hemostasis,clinical efficacy,adverse reactions were compared between the two groups.Levels of follicle stimulating hormone (FSH),luteinizing hormone (LH) and estradiol (E2)were detected.Results The total effectiveness rate was significantly higher in the study group than in the control group (97.87％ vs.53.19％,P＜0.05).Time to control of bleeding and time to complete s hemostasis was significantly shorter in the study group than in the control group.After treatment,FSH level was significantly decreased as compared with the control group (P＜0.05); Levels of FSH,LH and E2 did not differ significantly in the control group after treatment (P＞0.05).The rate of adverse reactions was significantly higher in the control group than in the study group (P＜0.05).Conclusions Desogestrel and ethinyl estradiol tablets is effective and safe in the treatment of perimenopausal dysfunctional uterine bleeding.The therapy is worth popularizing clinically.
