CAJ | 학술논문

目的：探讨性别差异与卒中患者相关性。方法检索2009年国外关于缺血脑卒中的危险因素、卒中类型及严重程度、诊断测试、卒中亚型、急性期和亚急性期的预防治疗与性别相关的比较研究，按预设的标准进行筛选。对纳入研究进行质量评价，并提取相关数据进行 Meta 分析，用优势比（OR）和95％置信区间（CI）评价，评估性别差异对脑卒中的影响。结果共纳入10篇符合标准的外文文献，总病例数436904例，纳入研究的人群中女性的卒中发病年龄晚于男性（5．2岁），患高血压（P ＜0．001）及房颤（P ＝0．04）比例更高；女性病人饮酒比例明显低于男性（P ＝0．04），吸烟比率也更低（P ＜0．001），但是高血脂比例明显高于男性（P ＝0．033）。脑卒中严重程度基线无性别差异。在抗卒中治疗方法中，女性接受相关抗血小板治疗（P ＜0．001）、他汀类降脂治疗（P ＜0．001）以及溶栓药物（tPA）治疗的有效率高于男性（P ＜0．001）。结论性别差异在脑卒中的危险因素、诊断及治疗手段方面存在差异性。在临床诊断及治疗过程中应该积极避免。
목적：탐토성별차이여졸중환자상관성。방법검색2009년국외관우결혈뇌졸중적위험인소、졸중류형급엄중정도、진단측시、졸중아형、급성기화아급성기적예방치료여성별상관적비교연구，안예설적표준진행사선。대납입연구진행질량평개，병제취상관수거진행 Meta 분석，용우세비（OR）화95％치신구간（CI）평개，평고성별차이대뇌졸중적영향。결과공납입10편부합표준적외문문헌，총병례수436904례，납입연구적인군중녀성적졸중발병년령만우남성（5．2세），환고혈압（P ＜0．001）급방전（P ＝0．04）비례경고；녀성병인음주비례명현저우남성（P ＝0．04），흡연비솔야경저（P ＜0．001），단시고혈지비례명현고우남성（P ＝0．033）。뇌졸중엄중정도기선무성별차이。재항졸중치료방법중，녀성접수상관항혈소판치료（P ＜0．001）、타정류강지치료（P ＜0．001）이급용전약물（tPA）치료적유효솔고우남성（P ＜0．001）。결론성별차이재뇌졸중적위험인소、진단급치료수단방면존재차이성。재림상진단급치료과정중응해적겁피면。
Objective The study is to analyse the correlation between stroke and gender .Methods We re‐view the overseas contrastive studies during 2009 on the correlation between the gender difference and the risk factors ,the types ,the severity ,the diagnosis and the test and the prevention and treatment for ische‐mic stroke .These studies were sorted out according to preset criteria and the relevant data were evaluated by using Meta analysis ,OR and CI .Results 10 studies were included in the research .The total cases were 436 904 .Based on the analysis ,the stroke onset age in female patients is 5 .2 years later than male pa‐tients .The incidence of high blood pressure (P < 0 .001) and the atrial filbrillation (P = 0 .04) is higher in female patients .Female patients drink and smoke significantly less than male petients ,but with much higher cholesterol ratio than male patients (P = 0 .033) .There is no significant difference in the severity of the stroke between female and male .In the treatment of stroke method ,the effective rate is higher than the male female ,in antiplatelet therapy (P < 0 .001) .Strains lipid‐lowering therapy (P < 0 .001) and tPA thrombolysis therapy (P < 0 .001) .Conclusion There are many differences in the risk factors ,disgnosis and treatment between female and male patients .The differences should be taken into consideration during the process of diagnosis and treatment .