CAJ | 학술논문

目的：探讨人乳头瘤病毒感染（HPV）及负荷量对宫颈癌前病变及宫颈癌的作用。方法选择2009年3月－2012年3月在新疆医科大学附属肿瘤医院经病理检查确诊的宫颈病变患者1326例为研究对象，其中慢性宫颈炎1000例，CIN Ⅰ52例，CIN Ⅱ40例，CIN Ⅲ142例，宫颈癌92例，采用杂交捕获二代（HC‐Ⅱ）方法定量检测宫颈 HPV‐DNA 的含量。结果（1）慢性宫颈炎组、CIN 组、宫颈癌组 HPV‐DNA 阳性率分别为13．5％、67．9％、94．5％，各组阳性率随着宫颈病变的程度加重而增加（P ＜0．001）。（2）CIN Ⅰ组、CIN Ⅱ组、CNI Ⅲ组中HPV‐DNA 阳性率分别为46．2％、57．5％、78．8％，各组阳性率随着 CIN 级别增高而增高（P ＜0．001）。（3）在HPV‐DNA 负荷量＞500时，HPV‐DNA 病毒负荷量随着宫颈病变程度的加重而增加，组间比较差异有统计学意义（P ＜0．001）。结论 HPV‐DNA 病毒感染及其负荷量与宫颈癌前病变及宫颈癌发生有关；HC‐Ⅱ检测对预测CIN 、宫颈癌发展有重要意义。
목적：탐토인유두류병독감염（HPV）급부하량대궁경암전병변급궁경암적작용。방법선택2009년3월－2012년3월재신강의과대학부속종류의원경병리검사학진적궁경병변환자1326례위연구대상，기중만성궁경염1000례，CIN Ⅰ52례，CIN Ⅱ40례，CIN Ⅲ142례，궁경암92례，채용잡교포획이대（HC‐Ⅱ）방법정량검측궁경 HPV‐DNA 적함량。결과（1）만성궁경염조、CIN 조、궁경암조 HPV‐DNA 양성솔분별위13．5％、67．9％、94．5％，각조양성솔수착궁경병변적정도가중이증가（P ＜0．001）。（2）CIN Ⅰ조、CIN Ⅱ조、CNI Ⅲ조중HPV‐DNA 양성솔분별위46．2％、57．5％、78．8％，각조양성솔수착 CIN 급별증고이증고（P ＜0．001）。（3）재HPV‐DNA 부하량＞500시，HPV‐DNA 병독부하량수착궁경병변정도적가중이증가，조간비교차이유통계학의의（P ＜0．001）。결론 HPV‐DNA 병독감염급기부하량여궁경암전병변급궁경암발생유관；HC‐Ⅱ검측대예측CIN 、궁경암발전유중요의의。
Objective To explore HPV infection and loads on cervical carcinoma and Cervical Intraepithelial neoplasia .Methods 1 326 cervical cancer sufferers were confirmed by pathological examina‐tion from march 2009 to march 2012 and were taken as subjects ,including 1 000 chronic cervicitis cases , 52 CIN Ⅰ cases ,40 CIN cases ,142 CIN Ⅲ cases ,92 cervical cancer cases .Results (1) The rate of HR‐HPV infection was 13 .5% in cervicitis ,67 .9% in CIN ,94 .5% in Cervical Cancer ,each positive rate in‐creased as the degree of cervical lesion increases (P < 0 .001) ;(2) The rate of HR‐HPV infection was 46 .2% in CIN Ⅰ ,57 .5% in CIN Ⅱ ,78 .8% in CIN Ⅲ ,each positive rate increased as the CIN level increased (P < 0 .001 ) ; (3 ) The comparison among four groups show that the distribution of HPV quantity was significantly different if HPV‐DNA > 500 (P < 0 .001) .Conclusion The viral loads of HPV DNA have a correlation with the grade of Cervial Cancer ,HC‐ Ⅱ test has important significance in CIN and the cervical cancer screening .