CAJ | 학술논문

目的：探讨普瑞巴林治疗神经病理性疼痛的疗效其安全性。方法将58例神经病理性疼痛患者随机分为普瑞巴林组和卡马西平组各29例，分别给予普瑞巴林和卡马西平治疗，所有入组患者均在治疗前及治疗1、2、3、4周时应用疼痛视觉模拟评分法（VAS）、睡眠干扰评分法、汉密尔顿抑郁量表（HAMD）及汉密尔顿焦虑量表（HAMA）进行疗效评定，同时观察两组不良反应情况。结果两组患者治疗后VAS评分、睡眠干扰评分、HAMD、HAMA评分较治疗前均有所降低（P＜0.05）；相同治疗时间内普瑞巴林组比卡马西平组评分降低明显（P＜0.05）；治疗过程中普瑞巴林组不良反应发生率较卡马西平组低（P＜0.05）。结论普瑞巴林治疗神经病理性疼痛疗效好，不良反应发生率低。
목적：탐토보서파림치료신경병이성동통적료효기안전성。방법장58례신경병이성동통환자수궤분위보서파림조화잡마서평조각29례，분별급여보서파림화잡마서평치료，소유입조환자균재치료전급치료1、2、3、4주시응용동통시각모의평분법（VAS）、수면간우평분법、한밀이돈억욱량표（HAMD）급한밀이돈초필량표（HAMA）진행료효평정，동시관찰량조불량반응정황。결과량조환자치료후VAS평분、수면간우평분、HAMD、HAMA평분교치료전균유소강저（P＜0.05）；상동치료시간내보서파림조비잡마서평조평분강저명현（P＜0.05）；치료과정중보서파림조불량반응발생솔교잡마서평조저（P＜0.05）。결론보서파림치료신경병이성동통료효호，불량반응발생솔저。
Objective To investigate the efficacy and safety of pregabalin in patients with neuropath-ic pain. Methods Fifty-eight patients with neuropathic pain were randomly divided into pregabalin treatment group (n=29 )and carbamazepine treatment group (n=29 ). The treatment efficacy were evaluated in two groups with visual analogue scale (VAS ),sleep disturbance evaluation method,Hamilton depression rating scale (HAMD)and Hamilton Anxiety Scale (HAMA)before the initiation of treatment and 1 w,2 w,3 w,4 w after treatment. Meanwhile,the adverse effects in two groups were observed. Results Scores of VAS,sleep disturbance evaluation method,HAMD and HAMA after treatment were lower than that before treatment in both two groups (P<0.05 ). Compared with carbamazepine group,pregabalin group had fewer scores and adverse effects at the same point in time (P<0.05 ). Conclusion Pregabalin exhibits much better efficacy and fewer adverse effects in patients with neuropathic pain.