CAJ | 학술논문

#细胞凋亡紊乱在消化道肿瘤的发生、发展过程中起着重要作用。BNIP3作为Bcl-2蛋白家族中BH3-only亚家族的成员之一，具有BH3结构域和TM跨膜结构区，属于线粒体促凋亡蛋白。BNIP3可通过Caspase非依赖性线粒体凋亡途径诱导细胞死亡，还可以介导自噬性细胞死亡，其表达受缺氧及其他因素的影响。BNIP3在肿瘤中的表达具有组织特异性，在乳腺癌、肺癌和宫颈癌等肿瘤中BNIP3高表达，而在胰腺癌、胃癌和结直肠癌中BNIP3则表达沉默。BNIP3在肿瘤中的表达缺失可导致肿瘤细胞耐受缺氧，对放化疗产生抵抗。全面了解BNIP3在各种肿瘤中的表达谱，可能使BNIP3成为临床指导肿瘤治疗及判断肿瘤预后的新靶标。
#세포조망문란재소화도종류적발생、발전과정중기착중요작용。BNIP3작위Bcl-2단백가족중BH3-only아가족적성원지일，구유BH3결구역화TM과막결구구，속우선립체촉조망단백。BNIP3가통과Caspase비의뢰성선립체조망도경유도세포사망，환가이개도자서성세포사망，기표체수결양급기타인소적영향。BNIP3재종류중적표체구유조직특이성，재유선암、폐암화궁경암등종류중BNIP3고표체，이재이선암、위암화결직장암중BNIP3칙표체침묵。BNIP3재종류중적표체결실가도치종류세포내수결양，대방화료산생저항。전면료해BNIP3재각충종류중적표체보，가능사BNIP3성위림상지도종류치료급판단종류예후적신파표。
Apoptosis disorders have an important function in the development of gastrointestinal cancer. BNIP3 is a member of the BH3-only subfamily of the bcl-2 family, which contains a BH3 domain and a transmembrane domain, and belongs to the mitochon-drial pro-apoptotic proteins. BNIP3 induces cell death via the caspase-independent mitochondrial apoptotic pathway and mediates au-tophagic cell death. BNIP3 expression is regulated by hypoxia and other factors. BNIP3 expression in tumors exhibits tissue specificity;BNIP3 is highly expressed in some tumors, including breast, lung, and cervical tumors. In pancreatic, gastric, and colorectal cancers, BNIP3 is epigenetically silenced. The absence of BNIP3 in the tumors can cause tumor cells to tolerate hypoxia and may be associated with chemotherapy and radiotherapy resistance. A comprehensive understanding of the spectrum of BNIP3 expression in a various tu-mors is necessary to use BNIP3 as a marker in clinical applications to treat tumors and as a new target in tumor prognosis.