CAJ | 학술논문

在经氨基修饰的Si O 2微球表面包裹氧化石墨烯,制备核壳结构的 SiO2-NH2@GO 复合微球。采用傅立叶转换-红外光谱仪(FT-IR)、扫描电子显微镜(SEM)、透射电子显微镜(TEM)和紫外分光光度计(UV)等对样品进行表征与分析。结果表明,SiO2-NH2@GO 复合微球具有良好的单分散性(粒径约为550 nm),并且 GO 均匀地包裹在 SiO2表面。与纯SiO2相比,SiO2-NH2@GO 通过布洛芬溶液浸泡载药的载药率有了较大提高,从42.9%提高到了68.8%,并且表现出更好的缓释性,24 h 累积释药量达到92%,给药时间延长20 h左右。表明 SiO2-NH2@GO复合微球有望成为一种新的药物载体。
재경안기수식적Si O 2미구표면포과양화석묵희,제비핵각결구적 SiO2-NH2@GO 복합미구。채용부립협전환-홍외광보의(FT-IR)、소묘전자현미경(SEM)、투사전자현미경(TEM)화자외분광광도계(UV)등대양품진행표정여분석。결과표명,SiO2-NH2@GO 복합미구구유량호적단분산성(립경약위550 nm),병차 GO 균균지포과재 SiO2표면。여순SiO2상비,SiO2-NH2@GO 통과포락분용액침포재약적재약솔유료교대제고,종42.9%제고도료68.8%,병차표현출경호적완석성,24 h 루적석약량체도92%,급약시간연장20 h좌우。표명 SiO2-NH2@GO복합미구유망성위일충신적약물재체。
The silica@graphene oxide (SiO2-NH2@GO)microspheres with core-shell structure were synthesized through the electrostatic interactions by encapsulation of graphene oxide on the surface of amino modified silica microspheres.The as-prepared microspheres were characterized by FT-IR,SEM,TEM and UV,etc.The re-sults show that the SiO2-NH2@GO microspheres are monodispersed with the diameter of 550 nm.GO wrapped on SiO2 surface evenly which were examined by SEM and TEM.Compared with pure SiO2 ,the drug loading of SiO2-NH2@GO microspheres was increased highly from 42.9% to 68.8% after immersed in ibuprofen solu-tion,the 92% drug was released after soaked for 24 h and the administration time was prolonged about 20 h. This implies that the monodispersed SiO2-NH2@GO microspheres synthesized in this work have potential usage as drug carriers in the biomedical fields.