CAJ | 학술논문

目的：探讨男性2型糖尿病患者骨密度的变化，并就血脂水平对骨质疏松的可能影响进行研究。方法测定男性2型糖尿病患者骨质疏松组(OP)及非骨质疏松组(NOP)的左股骨颈及腰椎L2~L4的骨密度，测定空腹血清中血脂浓度(总胆固醇、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇)的浓度，并对骨密度与多个变量之间的关系进行多元逐步回归分析。结果男性2型糖尿病伴骨质疏松患者低密度脂蛋白水平高于非骨质疏松组，而OP组各部位骨密度均低于 NOP组，两组腰椎L2~L4和股骨颈骨密度之间差异具有显著性(P＜0.01)；OP组血清中LDL-C与腰椎L2~L4及股骨颈骨密度呈负相关，HDL-C与与股骨颈骨密度呈正相关。结论男性2型糖尿病患者骨密度的降低和低密度脂蛋白水平相关。
목적：탐토남성2형당뇨병환자골밀도적변화，병취혈지수평대골질소송적가능영향진행연구。방법측정남성2형당뇨병환자골질소송조(OP)급비골질소송조(NOP)적좌고골경급요추L2~L4적골밀도，측정공복혈청중혈지농도(총담고순、감유삼지、저밀도지단백담고순、고밀도지단백담고순)적농도，병대골밀도여다개변량지간적관계진행다원축보회귀분석。결과남성2형당뇨병반골질소송환자저밀도지단백수평고우비골질소송조，이OP조각부위골밀도균저우 NOP조，량조요추L2~L4화고골경골밀도지간차이구유현저성(P＜0.01)；OP조혈청중LDL-C여요추L2~L4급고골경골밀도정부상관，HDL-C여여고골경골밀도정정상관。결론남성2형당뇨병환자골밀도적강저화저밀도지단백수평상관。
Objective To investigate the changes of bone mineralldensity (BMD) in men with type 2 diabetes patients and to study the Effects of the lipid levellon the density. Methods Determined the bone mineralldensity (BMD) of left femorallneck and lumbar spine (L2-L4).The hemolipid concentration (totallcholesterol,triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol)were evaluated.Finally,the relationship between bone density and severallvariables was studied using multiple regression analysis. Results Compared with non-osteoporosis group (NOP),in the men with type 2 diabetic osteoporosis group (OP),the LDL-C levellincreased significantly,while the BMD of lumbar spine L2-L4 and femorallneck was significantly lower; The LDL-C levellwas negatively correlated with BMD of lumbar spine (L2-L4);The HDL-C levellwas positively correlated with BMD of femorallneck. Conclusion Decrease of bone mineralldensity in type 2 diabetic male patients may be related to the development of the LDL-C level.