CAJ | 학술논문

目的：研究石榴皮提取物对试验性糖尿病小鼠肝脏抗氧化能力的影响。方法：用高、中、低剂量的石榴皮提取物治疗糖尿病小鼠5周后，观察其一般状况、肝脏的抗氧化能力及肝脏组织形态学变化。结果：石榴皮提取物治疗组，与糖尿病模型组比较，血糖显著降低（P＜0．05），丙二醛（MDA）、谷胱甘肽过氧化物酶（GSH-Px）显著降低、过氧化氢酶（CAT）显著降低（P＜0．01），超氧化物歧化酶（SOD）显著增加（P＜0．05），高剂量组谷胱甘肽（GSH）显著增加（P＜0．01），低剂量组一氧化氮合酶（NOS）显著降低（P＜0．01），一氧化氮（NO）、谷胱甘肽转硫酶（ GST）没有差异。光镜下石榴皮提取物治疗组肝组织细胞损伤较糖尿病组降低。结论：石榴皮提取物具有增强肝脏的抗氧化能力和保护肝组织细胞，降低肝细胞损伤作用。
목적：연구석류피제취물대시험성당뇨병소서간장항양화능력적영향。방법：용고、중、저제량적석류피제취물치료당뇨병소서5주후，관찰기일반상황、간장적항양화능력급간장조직형태학변화。결과：석류피제취물치료조，여당뇨병모형조비교，혈당현저강저（P＜0．05），병이철（MDA）、곡광감태과양화물매（GSH-Px）현저강저、과양화경매（CAT）현저강저（P＜0．01），초양화물기화매（SOD）현저증가（P＜0．05），고제량조곡광감태（GSH）현저증가（P＜0．01），저제량조일양화담합매（NOS）현저강저（P＜0．01），일양화담（NO）、곡광감태전류매（ GST）몰유차이。광경하석류피제취물치료조간조직세포손상교당뇨병조강저。결론：석류피제취물구유증강간장적항양화능력화보호간조직세포，강저간세포손상작용。
TO study the effect of pomegranate peel extract on liver antioxidant ability in experimental diabetic mice ,diabetic mice were treated with pomegranate peel extract (0.2、0.4、0.8g /kg.BW) respectively.After 5 weeks, the commonly status, liver antioxi-dant ability and the change of livers histological were observed .The treatment diabetic mice groups of pomegranate peel extract were compared with the experimental diabetic mice group .The level of blood glucose was reduced significantly (P<0.05), maleic dialde-hyde(MDA), Glutathione peroxidase (GSHPx) and catalase (CAT) were reduced significantly(P<0.01),Superoxide dismutase (SOD) and the levels of glutathione (GSH) of high doses was increased remarkably (P<0.05).nitric oxide synthase( NOS) of low doses was reduced significantly (P<0.01),nitric oxide (NO) and glutathione S-transferase(GST) were not different .The liver histo-logical damages of pomegranate peel extract treatment group were abated with DM group under light microscope observation .The extract of pomegranate peel can effectively enhance the liver antioxidant function and protect liver cells , decrease liver cell damages .