CAJ | 학술논문

目的：分析常规剂量甲泼尼龙、泼尼松序贯疗法在原发性肾病综合征中的治疗过程中，对患者尿蛋白及血浆白蛋白的影响。方法80例原发性肾病综合征患者依病理类型分为2组，A 组应用糖皮质激素，B 组为应用糖皮质激素加细胞毒类药物。再将2组各随机分为2组，即应用甲泼尼龙组（治疗组）、口服泼尼松组（对照组），进行疗效分析。结果常规剂量甲泼尼龙、泼尼松序贯疗法较常规泼尼松疗法，在尿蛋白的减少机血浆白蛋白的恢复方面均优于对照组，差异有统计学意义（P ＜0．05）。结论常规剂量甲泼尼龙、泼尼松序贯疗法在原发性肾病综合征治疗中较常规泼尼松应用能较快的减少尿蛋白及提高血浆白蛋白的水平。
목적：분석상규제량갑발니룡、발니송서관요법재원발성신병종합정중적치료과정중，대환자뇨단백급혈장백단백적영향。방법80례원발성신병종합정환자의병리류형분위2조，A 조응용당피질격소，B 조위응용당피질격소가세포독류약물。재장2조각수궤분위2조，즉응용갑발니룡조（치료조）、구복발니송조（대조조），진행료효분석。결과상규제량갑발니룡、발니송서관요법교상규발니송요법，재뇨단백적감소궤혈장백단백적회복방면균우우대조조，차이유통계학의의（P ＜0．05）。결론상규제량갑발니룡、발니송서관요법재원발성신병종합정치료중교상규발니송응용능교쾌적감소뇨단백급제고혈장백단백적수평。
Objective To analyze theefficacyof urine protein and plasma - albumin withregular dose methylprednisolone , prednisone of sequential therapy in primary nephrotic syndrome .Methods 80 patients with primary nephrotic syndrome were divided into two groups according to pathological type , glucocorticoids group ( A ) , and another group ( B) with glucocorticoid and cytotoxic drugs . Then each groupwas randomly divided into two groups , namely , the application of methylprednisolone group ( treatment group) and oral prednisone group ( control group) , and made an curative effect analysis .Results The effect of the 24 hour urinary protein excretion , plasma albumin ,cholesterol in treatment groupwas superior to those in the control group , There was no significantstatistical difference (P < 0 .05 ) . Conclusion The treatment of the regular dose of methylprednisolone , prednisone sequential therapy can more quickly relieve the urine protein and increase plasma-albuminthan regular prednisone application in primary nephrotic syndrome .