CAJ | 학술논문

对猪流行性腹泻的流行病学、病理学和防控研究新进展进行了综述。2013年发现该病在美国和古巴也有流行，乳汁和猫可能在传播中起作用。病毒表达的 S 蛋白含有该蛋白从内质网、高尔基体运送到细胞膜的信号，参与猪流行性腹泻病毒（PEDV）的复制和 PEDV 感染引起的神经系统病变。N 蛋白参与病毒的复制和转录，通过延长 S 期抑制肠上皮细胞生长，并且刺激上皮细胞高水平表达 IL-8。E 蛋白可上调IL-8的表达，但不调节肠上皮细胞的细胞周期。ORF3具多态性，可调节病毒的繁殖。Ⅰ型干扰素对病毒的抑制涉及 PLP2蛋白使 RIG-I 和 STING 去泛素化干扰 RIG-I 和 STING 介导的信号传导过程。槲皮素-7-鼠李糖苷、朝鲜淫羊藿的水提物具有很好的抗病毒活性。PED 的研究在以下方面还有待深入，如病毒的侵入、复制机制，疫苗免疫保护机制，抗病毒活性物质在生产实际中的效果。
대저류행성복사적류행병학、병이학화방공연구신진전진행료종술。2013년발현해병재미국화고파야유류행，유즙화묘가능재전파중기작용。병독표체적 S 단백함유해단백종내질망、고이기체운송도세포막적신호，삼여저류행성복사병독（PEDV）적복제화 PEDV 감염인기적신경계통병변。N 단백삼여병독적복제화전록，통과연장 S 기억제장상피세포생장，병차자격상피세포고수평표체 IL-8。E 단백가상조IL-8적표체，단불조절장상피세포적세포주기。ORF3구다태성，가조절병독적번식。Ⅰ형간우소대병독적억제섭급 PLP2단백사 RIG-I 화 STING 거범소화간우 RIG-I 화 STING 개도적신호전도과정。곡피소-7-서리당감、조선음양곽적수제물구유흔호적항병독활성。PED 적연구재이하방면환유대심입，여병독적침입、복제궤제，역묘면역보호궤제，항병독활성물질재생산실제중적효과。
The research progresses on epidemiology,pathogenesis and prevention of PED were summarized.PED was firstly reported in the United States and Cuba in 2013.Milk and cats may play a role in the spread of this dis-ease.S protein expressed by PEDV have signals on carrying S protein from endoplasmic reticulum,Golgi apparatus to membrane.This protein participates in PEDV replication and nervous system pathogenesis caused by PEDV in-fection.N protein involves in virus replication and transcription and inhibites intestinal epithelial cell growth by ex-tending S phase of its cell cycle,and stimulates the high level expression of IL-8 in intestinal epithelial cells.E pro-tein stimulates the high level expression of IL-8 in epithelial cells and does not regulate intestinal epithelial cell growth.ORF3 has polymorphism with adjustment of the virus reproduction.Interferon inhibition on PEDV is done by RIG-I and STING deubiquitylation induced by PLP2.Quercetin-7-rhamnoside,aqueous extract of Korea Epime-dium have good anti-PEDV activity.PED researches remaine to be further in the following respects,for example, mechanism of PEDV viruse invasion and replication,preventive immune responses on PEDV infection and clinical effects of materials with anti-PEDV activity.