CAJ | 학술논문

综述了环境与遗传交互作用对老龄健康影响的文献和国际研究进展，概述三个相关前期研究案例：FOXO基因类型与高龄老人60岁左右和当前喝茶的交互作用显著影响高龄老人健康，携带FOXO基因者喝茶对认知功能改善作用比不携带 FOXO 基因者显著要大；ADRB2-rs1042718或 ADRB2-rs1042719基因类型与经常锻炼和参加社会休闲活动的交互作用对高龄老人认知功能和自评健康有显著改善；APOE4基因与生活重压交互作用会显著诱发老人自评健康差。根据研究分析结论，建议在保护个人隐私前提下，充分考虑环境因素与基因类型交互作用，实行有的放矢的健康干预方案，可能大大提高老龄健康干预效益。
종술료배경여유전교호작용대노령건강영향적문헌화국제연구진전，개술삼개상관전기연구안례：FOXO기인류형여고령노인60세좌우화당전갈다적교호작용현저영향고령노인건강，휴대FOXO기인자갈다대인지공능개선작용비불휴대 FOXO 기인자현저요대；ADRB2-rs1042718혹 ADRB2-rs1042719기인류형여경상단련화삼가사회휴한활동적교호작용대고령노인인지공능화자평건강유현저개선；APOE4기인여생활중압교호작용회현저유발노인자평건강차。근거연구분석결론，건의재보호개인은사전제하，충분고필배경인소여기인류형교호작용，실행유적방시적건강간예방안，가능대대제고노령건강간예효익。
This paper presents a summarized review of the literature and international research program progress about investigations of effects of interactions between environmental and genetic factors (GxE) on health aging .We also briefly review three of our prior researches in this field ,including :Interactions between carrying the FOXO genotypes and tea drinking around age 60 or at present were significantly associated with lower risk of cognitive disability at advanced ages ;Interactions between carrying the minor allele rs1042718 or rs1042719 of ADRB2 gene and regular exercise or social-leisure activities predicted significantly increased cognitive function and the likelihood of self-reporting good health at advanced ages ;Interactions between carrying the APOE4 genotype and the life stress factors significantly increased the risk of poor self-rated health among older adults .Our review and analysis imply that health promotion and intervention programs considering individuals’ genetic profiles as well as the GxE effects ,with appropriate protection of privacy/confidentiality , would yield increased benefits and reduced costs to the programs and their participants .