中国医药科学
中國醫藥科學
중국의약과학
CHINA MEDICINE AND PHARMACY
2014年
18期
23-25,33
,共4页
王健%戴云湘%郑玮%毛拥军
王健%戴雲湘%鄭瑋%毛擁軍
왕건%대운상%정위%모옹군
内皮型一氧化氮合酶%基因多态性%老年原发性高血压%微量白蛋白尿
內皮型一氧化氮閤酶%基因多態性%老年原髮性高血壓%微量白蛋白尿
내피형일양화담합매%기인다태성%노년원발성고혈압%미량백단백뇨
Endothelial nitric oxide synthase%Genetic polymorphism%Essential hypertension in elderly patients%Microalbuminuria
目的:研究内皮型一氧化氮合酶(eNOS)Glu298Asp基因多态性与老年原发性高血压(EH)微量白蛋白尿(MAU)的关系。方法从到医院就诊的老年EH患者中筛选出202例无显性蛋白尿的患者,行24h MAU测定,并应用基因芯片技术检测eNOS Glu298Asp基因多态性,按照24hMAU定量分为MAU组和非MAU组(NAU组),比较两组基因型和等位基因分布差异。结果两组等位基因和基因型的分布不同,MAU组等位基因T及含等位基因T的基因型(GT+TT)分布频率明显升高(x2=6.62,P<0.01;x2=7.29,P<0.01);T等位基因变异使老年EH患者MAU的相对危险度显著增高(OR=2.361,95%CI=1.256~4.437)。结论T等位基因是老年EH患者MAU的易感基因,携带T等位基因导致老年EH患者出现MAU的风险显著增高。
目的:研究內皮型一氧化氮閤酶(eNOS)Glu298Asp基因多態性與老年原髮性高血壓(EH)微量白蛋白尿(MAU)的關繫。方法從到醫院就診的老年EH患者中篩選齣202例無顯性蛋白尿的患者,行24h MAU測定,併應用基因芯片技術檢測eNOS Glu298Asp基因多態性,按照24hMAU定量分為MAU組和非MAU組(NAU組),比較兩組基因型和等位基因分佈差異。結果兩組等位基因和基因型的分佈不同,MAU組等位基因T及含等位基因T的基因型(GT+TT)分佈頻率明顯升高(x2=6.62,P<0.01;x2=7.29,P<0.01);T等位基因變異使老年EH患者MAU的相對危險度顯著增高(OR=2.361,95%CI=1.256~4.437)。結論T等位基因是老年EH患者MAU的易感基因,攜帶T等位基因導緻老年EH患者齣現MAU的風險顯著增高。
목적:연구내피형일양화담합매(eNOS)Glu298Asp기인다태성여노년원발성고혈압(EH)미량백단백뇨(MAU)적관계。방법종도의원취진적노년EH환자중사선출202례무현성단백뇨적환자,행24h MAU측정,병응용기인심편기술검측eNOS Glu298Asp기인다태성,안조24hMAU정량분위MAU조화비MAU조(NAU조),비교량조기인형화등위기인분포차이。결과량조등위기인화기인형적분포불동,MAU조등위기인T급함등위기인T적기인형(GT+TT)분포빈솔명현승고(x2=6.62,P<0.01;x2=7.29,P<0.01);T등위기인변이사노년EH환자MAU적상대위험도현저증고(OR=2.361,95%CI=1.256~4.437)。결론T등위기인시노년EH환자MAU적역감기인,휴대T등위기인도치노년EH환자출현MAU적풍험현저증고。
Objective To investigate the association between endothelial nitric oxide synthase (eNOS)gene Glu298Asp polymorphisms and microalbuminuria(MAU) in elderly patients with essential hypertension(EH). Methods 24-hour microalbuminuria the whole day was quantified in 202 elderly patients with EH,but without dominant proteinuria. and eNOS gene Glu298Asp polymorphisms was assayed by gene chip technology.According to 24-hour microalbuminuria,patients were divided into two groups:microalminuria group(MAUgroup) and normoalbuminuria group(NAUgroup).The allele and genotype frequency distributions were compared between the two groups. Results In the two groups there are different distribution frequencies beteen G allele and T allele.So was among the three genotypes(GG,GT and TT).The frequencies of T allele and the genotypes with T allele in the MAU group were remarkably higher than the NAU group(x2=6.62, P<0.01;x2=7.29, P<0.01).Mutation of T allele caused a high relative ratio risk ratio of MAU in elderly patients with hypertension(OR=2.361,95%CI=1.256~4.437). Conclusion T alllele is one suscepitibity gene of elderly hypertensive patients with MAU.Elderly hypertensive patients carrying T allele are susceptible to MAU..