CAJ | 학술논문

目的：探讨非小细胞肺癌患者血清雌激素水平与肺癌组织中雌激素受体表达及其临床病理意义，为非小细胞肺癌的防治提供一些参考。方法选择2010年1月～2012年12月本院收治的经病理证实的肺腺癌患者36例作为观察组，同时选择同期在我院治疗的经病理学证实的肺鳞癌患者32例作为对照一组和来我院体检肺部健康的志愿者30例作为对照二组，然后利用免疫组织染色化学技术对所有参与实验的人员肺部组织进行瘦素、血清雌激素（E）及雌激素受体（ER）的检测，分别对观察组、对照一组、对照二组患者的瘦素、血清雌激素（E）及雌激素受体（ER）进行比较，然后对观察组男性肺腺癌患者和女性肺腺癌患者的瘦素、血清雌激素（E）及雌激素受体（ER）进行比较。结果观察组与对照一组、对照二组相比，瘦素、血清雌激素（E）及雌激素受体（ER）阳性表达明显高于其他两组，差异具有统计学意义（P＜0.05）；与男性相比较，观察组女性患者体内的瘦素、血清雌激素（E）阳性表达变化不显著（P＞0.05），但是女性患者中ER阳性表达显著高于男性，差异有统计学意义（P＜0.05）。结论非小细胞肺癌患者的瘦素、血清雌激素（E）、雌激素受体（ER）的阳性表达高于正常人的，说明这三种因素可能参加着非小细胞肺癌的发生，可作为诊断非小细胞肺癌的重要依据。
목적：탐토비소세포폐암환자혈청자격소수평여폐암조직중자격소수체표체급기림상병리의의，위비소세포폐암적방치제공일사삼고。방법선택2010년1월～2012년12월본원수치적경병리증실적폐선암환자36례작위관찰조，동시선택동기재아원치료적경병이학증실적폐린암환자32례작위대조일조화래아원체검폐부건강적지원자30례작위대조이조，연후이용면역조직염색화학기술대소유삼여실험적인원폐부조직진행수소、혈청자격소（E）급자격소수체（ER）적검측，분별대관찰조、대조일조、대조이조환자적수소、혈청자격소（E）급자격소수체（ER）진행비교，연후대관찰조남성폐선암환자화녀성폐선암환자적수소、혈청자격소（E）급자격소수체（ER）진행비교。결과관찰조여대조일조、대조이조상비，수소、혈청자격소（E）급자격소수체（ER）양성표체명현고우기타량조，차이구유통계학의의（P＜0.05）；여남성상비교，관찰조녀성환자체내적수소、혈청자격소（E）양성표체변화불현저（P＞0.05），단시녀성환자중ER양성표체현저고우남성，차이유통계학의의（P＜0.05）。결론비소세포폐암환자적수소、혈청자격소（E）、자격소수체（ER）적양성표체고우정상인적，설명저삼충인소가능삼가착비소세포폐암적발생，가작위진단비소세포폐암적중요의거。
Objective To explore the clinical pathological significance of estrogen receptor level of patients with non-small cell lung cancer and expression of serum estrogen level in lung cancer tissue for providing some reference on the prevention and control of non small cell lung cancer. Methods 36 patients with lung adenocarcinoma were selected as the observation group,who were pathologically confirmed and treated in our hospital from 2010 January to 2012 December,at the same time,32 patients with squamous cell lung carcinoma in the same period,who were pathologically confirmed and treated in our hospital,were selected as control 1 group,and 30 healthy volunteers in our hospital for medical examination of the lungs were selected as control 2 group.The lung tissue leptin,serum estradiol(E) and estrogen receptor(ER)of all the participants were detected by immunohistochemical staining technique.The serum leptin,estrogen(E)and estrogen receptor(ER) of observation group,control 1 group,and control 2 group were compared.In addition,the leptin,serum estrogen(E)and estrogen receptor(ER) of male and female patients with lung adenocarcinoma in the observation group were compared. Results The leptin,serum estradiol(E)and estrogen receptor(ER)positive expression of the observation group were significantly higher than those of the other two groups, and the differences were statistically significant(P < 0.05).Compared with male,the leptin and serum estrogen(E)positive expression of female patients in observation group did not change significantly(P > 0.05),but the positive expression of ER in female patients was significantly higher than that in male(P < 0.05). Conclusion The leptin,serum estrogen(E) and estrogen receptor(ER)positive expression of the non small cell lung cancer patients are higher than those of normal people.It shows that these three factors may participate in non small cell lung cancer,which can be used as an important basis for the diagnosis of non small cell lung cancer.