CAJ | 학술논문

　　目的综合评价血栓通治疗冠心病的有效性和安全性，为临床治疗决策提供科学依据。方法利用计算机检索文献，并进行筛选，在对纳入文献进行方法学质量评价后，应用 RevMan5.0软件，采用固定效应模型或随机效应模型对纳入文献进行Meta分析。结果本研究共纳入31篇文献，质量评级均为C级。在心电图总有效方面，血栓通单用VS复方丹参单用、血栓通联用其它药物VS复方丹参联用其它药物、血栓通联用硝酸甘油VS硝酸甘油、血栓通联用其它药物VS其它药物比较，RR及95%CI分别为1.45（1.29～1.62）、1.19（1.01～1.41）、1.22（1.10～1.34）、1.28（1.19～1.38），差异具有统计学意义。在心绞痛总有效方面，血栓通联用其它药物VS其它药物、血栓通联用硝酸甘油VS硝酸甘油比较，RR及95%CI分别为1.28（1.19～1.38）、1.30（1.15～1.48），差异具有统计学意义。敏感性分析验证了结果的稳定性。结论血栓通不论是单用还是与其它药物联合应用，在心绞痛和心电图总有效方面均较其它药物优秀。
　　목적종합평개혈전통치료관심병적유효성화안전성，위림상치료결책제공과학의거。방법이용계산궤검색문헌，병진행사선，재대납입문헌진행방법학질량평개후，응용 RevMan5.0연건，채용고정효응모형혹수궤효응모형대납입문헌진행Meta분석。결과본연구공납입31편문헌，질량평급균위C급。재심전도총유효방면，혈전통단용VS복방단삼단용、혈전통련용기타약물VS복방단삼련용기타약물、혈전통련용초산감유VS초산감유、혈전통련용기타약물VS기타약물비교，RR급95%CI분별위1.45（1.29～1.62）、1.19（1.01～1.41）、1.22（1.10～1.34）、1.28（1.19～1.38），차이구유통계학의의。재심교통총유효방면，혈전통련용기타약물VS기타약물、혈전통련용초산감유VS초산감유비교，RR급95%CI분별위1.28（1.19～1.38）、1.30（1.15～1.48），차이구유통계학의의。민감성분석험증료결과적은정성。결론혈전통불론시단용환시여기타약물연합응용，재심교통화심전도총유효방면균교기타약물우수。
Objective To evaluate efficacy and safety of Xueshuantong for coronary heart disease,from which to provide scientific proofs for clinical decision making. Methods We firstly retrieved and selected literatures,and the methodological quality evaluation of the included articles was fol owed.Afterwards, using Cochrane Col aboration’s software RevMan 5.0, we conducted Meta-analysis with fixed or random effect model. Results A total of thirty one papers were included in the study and the methodological quality was graded to C.When it comes to electrocardiogram total response rate, RRs and 95%CI were 1.45 (1.29~1.62), 1.19 (1.01~1.41), 1.22 (1.10~1.34), 1.28 (1.19~1.38)which indicated there were significant differences between Xueshuantong alone and Fufang Danshen alone, Xueshuantong+other drugs combination and Fufang Danshen+other drugs combination, Xueshuantong+Nitroglycerinum combination and Nitroglycerinum alone, Xueshuantong+other drugs combination and other drugs. As for angina total response rate, Significance differences were noted between Xueshuantong+other drugs combination and other drugs, Xueshuantong+Nitroglycerinum combination and Nitroglycerinum alone where RRs and 95%CI were 1.28 (1.19~1.38),1.30 (1.15~1.48). The sensitivity analysis tested and verified the reliability of the results above. Conclusions The adoption of Xueshuantong for coronary heart disease can improve total response rate.