医学信息
醫學信息
의학신식
MEDICAL INFORMATION
2014年
26期
446-446
,共1页
高血压%盐敏感性%非盐敏感性%联合治疗
高血壓%鹽敏感性%非鹽敏感性%聯閤治療
고혈압%염민감성%비염민감성%연합치료
Hypertension%Salt sensitivity%Non salt sensitive%Combined treatment
目的探讨盐敏感性与非盐敏感性高血压对靶器官的损害和联合药物治疗的差异。方法在住院的轻中度高血压患者中选取120例,经过盐负荷试验测试,确定60例为盐敏感性高血压组(SS),另选择60例作为非盐敏感性高血压组(NSS),再将这两组分别以每组30例随机分为两小组,分别用非洛地平片联合培哚普利片和吲达帕胺缓释片联合培哚普利片治疗12w,测量治疗前后24 h各指标的变化。结果 SS组与NSS组相比,FPG和Cr水平的不同有统计学意义(<0.01),FINS、LVMI、MAU、BMI、HOMA-IR的差异亦有统计学意义(<0.05)；SS组中的患者是使用培吲达帕胺联合哚普利进行治疗的,各项检测指标均位于正常范围内,差异有统计学意义(<0.05)；NSS组中的患者是使用非洛地平联合培哚普利进行治疗的,其各项检测指标都位于正常范围之内,差异有统计学意义(<0.05)。结论盐敏感性高血压患者的靶器官有明显损害,适于吲达帕胺与培哚普利联合药物治疗,而非盐敏感性患者适于非洛地平与培哚普利联合治疗。
目的探討鹽敏感性與非鹽敏感性高血壓對靶器官的損害和聯閤藥物治療的差異。方法在住院的輕中度高血壓患者中選取120例,經過鹽負荷試驗測試,確定60例為鹽敏感性高血壓組(SS),另選擇60例作為非鹽敏感性高血壓組(NSS),再將這兩組分彆以每組30例隨機分為兩小組,分彆用非洛地平片聯閤培哚普利片和吲達帕胺緩釋片聯閤培哚普利片治療12w,測量治療前後24 h各指標的變化。結果 SS組與NSS組相比,FPG和Cr水平的不同有統計學意義(<0.01),FINS、LVMI、MAU、BMI、HOMA-IR的差異亦有統計學意義(<0.05)；SS組中的患者是使用培吲達帕胺聯閤哚普利進行治療的,各項檢測指標均位于正常範圍內,差異有統計學意義(<0.05)；NSS組中的患者是使用非洛地平聯閤培哚普利進行治療的,其各項檢測指標都位于正常範圍之內,差異有統計學意義(<0.05)。結論鹽敏感性高血壓患者的靶器官有明顯損害,適于吲達帕胺與培哚普利聯閤藥物治療,而非鹽敏感性患者適于非洛地平與培哚普利聯閤治療。
목적탐토염민감성여비염민감성고혈압대파기관적손해화연합약물치료적차이。방법재주원적경중도고혈압환자중선취120례,경과염부하시험측시,학정60례위염민감성고혈압조(SS),령선택60례작위비염민감성고혈압조(NSS),재장저량조분별이매조30례수궤분위량소조,분별용비락지평편연합배타보리편화신체파알완석편연합배타보리편치료12w,측량치료전후24 h각지표적변화。결과 SS조여NSS조상비,FPG화Cr수평적불동유통계학의의(<0.01),FINS、LVMI、MAU、BMI、HOMA-IR적차이역유통계학의의(<0.05)；SS조중적환자시사용배신체파알연합타보리진행치료적,각항검측지표균위우정상범위내,차이유통계학의의(<0.05)；NSS조중적환자시사용비락지평연합배타보리진행치료적,기각항검측지표도위우정상범위지내,차이유통계학의의(<0.05)。결론염민감성고혈압환자적파기관유명현손해,괄우신체파알여배타보리연합약물치료,이비염민감성환자괄우비락지평여배타보리연합치료。
Objective To explore the value of transabdominal and transvaginal ultrasonography in diagnosis of pregnancy. Methods 120 cases in hospitalized patients with mild to moderate hypertension, after the salt load test tests to determine the 60 cases of salt-sensitive hypertension group (SS), another 60 patients as a non-salt-sensitive hypertension group (NSS) , and then the two groups were in groups of 30 cases were randomly divided into two groups, each with felodipine tablets combined perindopril and indapamide sustained release tablets tablets combined perindopril tablets for 12 weeks, measuring treatment change after 24 h of each index. Results SS group compared with the NSS group, dif erent levels of FPG and Cr were statistical y significant ( <0.01), the difference FINS, LVMI, MAU, BMI, HOMA-IR are also statistically significant ( <0.05 ); SS group of patients is the use of joint training indapamide perindopril treatment, and the detection of indicators are within the normal range, the difference was statistical y significant ( <0.05); NSS group of patients is the use of felodipine combined perindopril treatment, and its detection indicators are located within the normal range, the dif erence was statistical y significant ( <0.05).Conclusion Salt-sensitive hypertension obvious target organ damage, for indapamide and perindopril combination therapy, rather than salt-sensitive patients for felodipine combination therapy with perindopril.
