CAJ | 학술논문

目的：观察沙格列汀联合二甲双胍及二甲双胍单药治疗对初诊2型糖尿病患者胰岛β细胞功能的影响。方法初诊2型糖尿病患者66例随机分为沙格列汀联合二甲双胍治疗组（A组）33例、二甲双胍单药治疗组（B组）33例，测定治疗前及治疗24周后空腹血糖（FPG）、空腹胰岛素（FIns）、餐后2h血糖（2hPG）、糖化血红蛋白（HbA1C）、HOMA-β及HOMA-IR等。结果（1）治疗后两组受试者FPG、2hPG及HbA1C均较治疗前下降（P＜0.05），A组患者上述指标均低于B组（P＜0.05）；（2）治疗后两组受试者HOMA-β增加、HOMA-IR下降（P均＜0.05），但A组HOMA-β高于B组（P＜0.05）、而两组HOMA-IR无差异。结论对初诊2型糖尿病患者进行沙格列汀联合二甲双胍治疗可有效控制血糖，且沙格列汀可改善胰岛β细胞功能。
목적：관찰사격렬정연합이갑쌍고급이갑쌍고단약치료대초진2형당뇨병환자이도β세포공능적영향。방법초진2형당뇨병환자66례수궤분위사격렬정연합이갑쌍고치료조（A조）33례、이갑쌍고단약치료조（B조）33례，측정치료전급치료24주후공복혈당（FPG）、공복이도소（FIns）、찬후2h혈당（2hPG）、당화혈홍단백（HbA1C）、HOMA-β급HOMA-IR등。결과（1）치료후량조수시자FPG、2hPG급HbA1C균교치료전하강（P＜0.05），A조환자상술지표균저우B조（P＜0.05）；（2）치료후량조수시자HOMA-β증가、HOMA-IR하강（P균＜0.05），단A조HOMA-β고우B조（P＜0.05）、이량조HOMA-IR무차이。결론대초진2형당뇨병환자진행사격렬정연합이갑쌍고치료가유효공제혈당，차사격렬정가개선이도β세포공능。
Objective To evaluate the effect of saxagliptin in combination with metformin on β cell functions in newly diagnosed patients with type 2 diabetes. Methods It was a randomized observational study. At baseline,a total of 66 newly diagnosed patients with type 2 diabetes were randomly assigned to metformin plus saxagliptin therapy(group A,n=33) or metformin monotherapy(group B,n=33). The observational period lasted for 24 weeks. Repeated measures were utilized to evaluate changes from baseline in fasting plasma glucose(FPG),2-hour postprandial plasma glucose (2hPG), serum insulin concentrations, hemoglobin A1C(HbA1C),homeostasis model assessment index of insulin resistance (HOMA-IR) and β cell function (HOMA-β).HOMA-β was compared between group A and B. Results The levels of FPG,2hPG, HbA1C and HOMA-IR decreased significantly in both groups 24 weeks after the initiation (P<0.05).HOMA-β increased significantly in both groups (P<0.05).Compared with group B, there was significant reductions in FPG, 2hPG and HbA1C in group A,and increase in HOMA-β(P<0.05). Conclusion Saxagliptin as an add-on therapy to metformin not only benefits glucose control but also improvesβcell function.