中医临床研究
中醫臨床研究
중의림상연구
CLINICAL JOURNAL OF CHINESE MEDICINE
2013年
22期
9-11
,共3页
张丽红%肖晓金%杨真真%姜梦丽%李孝栋
張麗紅%肖曉金%楊真真%薑夢麗%李孝棟
장려홍%초효금%양진진%강몽려%리효동
组分中药%养血注射液%吸波面积法%药代动力学
組分中藥%養血註射液%吸波麵積法%藥代動力學
조분중약%양혈주사액%흡파면적법%약대동역학
Components of Chinese herbs%Yangxue injection%Area under absorbability-wavelength curve%Pharmacokinetics
目的:研究组分中药制剂养血注射液在大鼠体内的药代动力学。方法:配制阿魏酸、盐酸川芎嗪、丹参素钠等与处方量等比例的系列浓度混合对照品溶液,经紫外-可见分光光度法在200~600nm下全波长扫描,求算吸光度-波长曲线下面积(简称吸波面积,AUAWC),绘制药物总浓度-吸波面积的标准曲线。另大鼠尾静脉注射养血注射液,处理后的血浆经扫描获得吸波面积,将吸波面积代入线性方程,得到给药后不同时间药物总的血药浓度,通过3P97程序对血药浓度-时间数据进行房室模型拟合,获得药代动力学参数。结果:药物总浓度在0.448~14.325μg?ml-1范围内与吸波面积呈良好的线性关系,AUAWC=5.8577C+0.4472(r=1.0000)。养血注射液在大鼠体内的药时过程符合一室模型,分布迅速,消除快,总药物的药代动力学参数 C0为181.55μg?ml-1,t1/2为13.1min,AUC为3432.61μg?ml-1?min。结论:吸波面积法较好地阐述了养血注射液大鼠体内的药代动力学特征,为多成分组分中药制剂的体内研究和中医药现代化与国际化奠定基础。
目的:研究組分中藥製劑養血註射液在大鼠體內的藥代動力學。方法:配製阿魏痠、鹽痠川芎嗪、丹參素鈉等與處方量等比例的繫列濃度混閤對照品溶液,經紫外-可見分光光度法在200~600nm下全波長掃描,求算吸光度-波長麯線下麵積(簡稱吸波麵積,AUAWC),繪製藥物總濃度-吸波麵積的標準麯線。另大鼠尾靜脈註射養血註射液,處理後的血漿經掃描穫得吸波麵積,將吸波麵積代入線性方程,得到給藥後不同時間藥物總的血藥濃度,通過3P97程序對血藥濃度-時間數據進行房室模型擬閤,穫得藥代動力學參數。結果:藥物總濃度在0.448~14.325μg?ml-1範圍內與吸波麵積呈良好的線性關繫,AUAWC=5.8577C+0.4472(r=1.0000)。養血註射液在大鼠體內的藥時過程符閤一室模型,分佈迅速,消除快,總藥物的藥代動力學參數 C0為181.55μg?ml-1,t1/2為13.1min,AUC為3432.61μg?ml-1?min。結論:吸波麵積法較好地闡述瞭養血註射液大鼠體內的藥代動力學特徵,為多成分組分中藥製劑的體內研究和中醫藥現代化與國際化奠定基礎。
목적:연구조분중약제제양혈주사액재대서체내적약대동역학。방법:배제아위산、염산천궁진、단삼소납등여처방량등비례적계렬농도혼합대조품용액,경자외-가견분광광도법재200~600nm하전파장소묘,구산흡광도-파장곡선하면적(간칭흡파면적,AUAWC),회제약물총농도-흡파면적적표준곡선。령대서미정맥주사양혈주사액,처리후적혈장경소묘획득흡파면적,장흡파면적대입선성방정,득도급약후불동시간약물총적혈약농도,통과3P97정서대혈약농도-시간수거진행방실모형의합,획득약대동역학삼수。결과:약물총농도재0.448~14.325μg?ml-1범위내여흡파면적정량호적선성관계,AUAWC=5.8577C+0.4472(r=1.0000)。양혈주사액재대서체내적약시과정부합일실모형,분포신속,소제쾌,총약물적약대동역학삼수 C0위181.55μg?ml-1,t1/2위13.1min,AUC위3432.61μg?ml-1?min。결론:흡파면적법교호지천술료양혈주사액대서체내적약대동역학특정,위다성분조분중약제제적체내연구화중의약현대화여국제화전정기출。
Objective:To study pharmacokinetics of Yangxue injection in rats. Methods:Mixed reference substance solutions of a series of concentrations were made, in which the ratio of all constituents were the same as Yangxue injection. Area under the absorbability-wavelength curve (AUAWC) was obtained through a full ultraviolet-visible spectrum scan from 200 to 600 nm wavelength. The linear relationship between AUAWC and total medicine concentration was observed. Yangxue injection was administered to rats by tail vein injection. Plasma samples were collected at different times and treated with methanol to precipitate protein.AUAWC and total medicines’ concentrations in plasma were obtained after a full ultraviolet-visible spectrum scan. The mean plasma concentration-time data was processed with 3P97 soft procedure to obtain the main pharmacokinetics parameters of total components. Results: The calibration curve was linear in the range of 0.448~14.325μg?ml-1 (r=1.0000). After intravenous injection, the pharmacokinetics behavior of Yangxue injection fitted one compartment model in rats and both the distribution and the elimination were fast. The main pharmacokinetic parameters of total components were as follows:C0 was 181.55μg?ml-1, t1/2 was 13.1min, AUC was 3432.61μg?ml-1?min. Conclusion:The pharmacokinetic characteristics of Yangxue injection in rats was shown by the method of AUAWC, which will bring a feasible idea and pathway to pharmacokinetics’ studies and modernization of TCM.