中医临床研究
中醫臨床研究
중의림상연구
CLINICAL JOURNAL OF CHINESE MEDICINE
2013年
22期
7-8
,共2页
红曲%洛伐他汀%颈动脉粥样硬化
紅麯%洛伐他汀%頸動脈粥樣硬化
홍곡%락벌타정%경동맥죽양경화
Red rice%Lovastatin%Carotid atherosclerosis
目的：探讨红曲治疗颈动脉粥样硬化斑块的临床疗效。方法：60例经彩色多普勒超声检测证实有不同程度颈动脉粥样硬化斑块形成的患者，采用随机数字表法分为红曲治疗组和洛伐他汀治疗组各20例，另外20例患者作为空白对照组。红曲组予红曲治疗，6g/次，2次/d，饭后予开水150ml泡20min，红曲完全溶解后服用，连服6个月；洛伐他汀组予洛伐他汀胶囊20mg口服，1次/d，也连服6个月；对照组不予相关药物干预。观察用药6个月后中医证侯疗效及彩色多普勒超声检测颈动脉内膜-中膜厚度（IMT）和Crouse斑块积分的变化。结果：两治疗组治疗6个月后中医证侯明显改善，两治疗组组间比较无统计学意义；而空白对照组治疗前后中医证侯无变化甚至加重，与两治疗组比较有统计学意义。两治疗组治疗后 IMT和 Crouse斑块积分的均显著改善，两组间比较无统计学意义；而空白对照组治疗前后无变化甚至加重。结论：红曲与洛伐他汀均具有改善颈动脉粥样硬化患者临床症状及减轻和消退颈动脉粥样硬化的作用，且红曲副作用少，安全性大，值得临床应用。
目的：探討紅麯治療頸動脈粥樣硬化斑塊的臨床療效。方法：60例經綵色多普勒超聲檢測證實有不同程度頸動脈粥樣硬化斑塊形成的患者，採用隨機數字錶法分為紅麯治療組和洛伐他汀治療組各20例，另外20例患者作為空白對照組。紅麯組予紅麯治療，6g/次，2次/d，飯後予開水150ml泡20min，紅麯完全溶解後服用，連服6箇月；洛伐他汀組予洛伐他汀膠囊20mg口服，1次/d，也連服6箇月；對照組不予相關藥物榦預。觀察用藥6箇月後中醫證侯療效及綵色多普勒超聲檢測頸動脈內膜-中膜厚度（IMT）和Crouse斑塊積分的變化。結果：兩治療組治療6箇月後中醫證侯明顯改善，兩治療組組間比較無統計學意義；而空白對照組治療前後中醫證侯無變化甚至加重，與兩治療組比較有統計學意義。兩治療組治療後 IMT和 Crouse斑塊積分的均顯著改善，兩組間比較無統計學意義；而空白對照組治療前後無變化甚至加重。結論：紅麯與洛伐他汀均具有改善頸動脈粥樣硬化患者臨床癥狀及減輕和消退頸動脈粥樣硬化的作用，且紅麯副作用少，安全性大，值得臨床應用。
목적：탐토홍곡치료경동맥죽양경화반괴적림상료효。방법：60례경채색다보륵초성검측증실유불동정도경동맥죽양경화반괴형성적환자，채용수궤수자표법분위홍곡치료조화락벌타정치료조각20례，령외20례환자작위공백대조조。홍곡조여홍곡치료，6g/차，2차/d，반후여개수150ml포20min，홍곡완전용해후복용，련복6개월；락벌타정조여락벌타정효낭20mg구복，1차/d，야련복6개월；대조조불여상관약물간예。관찰용약6개월후중의증후료효급채색다보륵초성검측경동맥내막-중막후도（IMT）화Crouse반괴적분적변화。결과：량치료조치료6개월후중의증후명현개선，량치료조조간비교무통계학의의；이공백대조조치료전후중의증후무변화심지가중，여량치료조비교유통계학의의。량치료조치료후 IMT화 Crouse반괴적분적균현저개선，량조간비교무통계학의의；이공백대조조치료전후무변화심지가중。결론：홍곡여락벌타정균구유개선경동맥죽양경화환자림상증상급감경화소퇴경동맥죽양경화적작용，차홍곡부작용소，안전성대，치득림상응용。
Objective:To investigate the clinical effect on treating carotid atherosclerosis plaque with red rice. Methods:60 case of different degrees of carotid atherosclerotic plaque, randomly divided into red rice treated group and lovastatin treated group each of 20 cases, in the other 20 patients as control group. Red rice treated group was gave the rad rice, 6g/time, 2 time/d, 150ml to boiling water soak 20 minutes after a meal, to take after rad rice is completely dissolved, and even served 6 months;The control group did not related to medicine intervention. Observation TCM syndrome curative effect after 6 months and Color Doppler ultrasound detection of carotid intima-media thickness (IMT) and Crouse plaque integral. Results:The TCM syndrome significantly was improved after 6 months;there is no statistical significance between the two groups;before and after treatment the TCM syndrome without change of the control group, there was statistical significance compared with two in the treated group. Conclusion:Monascus and lovastatin has improved the clinical symptoms in patients with carotid atherosclerosis and reduce and regression of carotid atherosclerosis, Monascus has less side effect, high safety, and is worthy of clinical application.
